Assessment of potential therapies for acute T-2 toxicosis in the rat

Robert H Poppenga, Val Richard Beasley, William B. Buck

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The efficacy of a variety of approaches for the treatment of animals with acute T-2 toxicosis was assessed utilizing young female rats. A single large dose of the water soluble salt of methylprednisolone significantly prolonged survival times in T-2 toxin treated animals. The use of diltiazem hydrochloride, dazemgrel, N-acetylcysteine, dimethyl sulfoxide, adenosine triphosphate (ATP), ATP combined with magnesium chloride, ascorbic acid, and aprotinin did not prolong survival times at the dosages administered. Trichodermin, a trichothecene similar in structure and biochemical activity to T-2 toxin but much less acutely toxic, had a detrimental effect on survival times whether given 1 hr prior to or after T-2 toxin.

Original languageEnglish (US)
Pages (from-to)537-546
Number of pages10
JournalToxicon
Volume25
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

T-2 Toxin
Rats
Trichodermin
Animals
Adenosine Triphosphate
Trichothecenes
Magnesium Chloride
Aprotinin
Diltiazem
Saline water
Poisons
Methylprednisolone
Acetylcysteine
Dimethyl Sulfoxide
Ascorbic Acid
Therapeutics
Salts
Water

ASJC Scopus subject areas

  • Toxicology

Cite this

Assessment of potential therapies for acute T-2 toxicosis in the rat. / Poppenga, Robert H; Beasley, Val Richard; Buck, William B.

In: Toxicon, Vol. 25, No. 5, 1987, p. 537-546.

Research output: Contribution to journalArticle

Poppenga, Robert H ; Beasley, Val Richard ; Buck, William B. / Assessment of potential therapies for acute T-2 toxicosis in the rat. In: Toxicon. 1987 ; Vol. 25, No. 5. pp. 537-546.
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