Assessment of patent ductus arteriosus shunting using diastolic pressure analysis

Jay M Milstein, Thomas A. Riemenschneider, Boyd W. Goetzman, Lily George, Richard P. Wennberg

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Ductal shunting significantly affected the time necessary for aortic diastolic pressure to fall to one-halfan initially selected value (t1/2). Fourteen premature infants with clinical evidence of left-to-right ductal shunting had a mean t1/2 of 277 msec (range 133 to 383 msec) compared with a mean t1/2 of 455 msec (range 332 to 567 msec) in 14 neonates with no clinical evidence of ductal shungting (P<0.01). Seven older infants with ductal shunting confirmed at cardiac catheterization had a mean t1/2 of 360 msec (range 240 to 392 msec). Infant catheterization data and animal studies are suggestive of an inverse relationship between the magnitude of shunt and the t1/2. The t1/2 determined by diastolic pressure analysis is a useful method for serial evaluation of ductus arteriosus shunting.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalThe Journal of Pediatrics
Issue number1
StatePublished - 1979

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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