Assessment of nutritional status in rhesus monkeys: Comparison of dual-energy X-ray absorptiometry and stable isotope dilution

Stéphane Blanc, Ricki Colman, Joseph Kemnitz, Richard Weindruch, Scott Baum, Jon J Ramsey, Dale Schoeller

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Body composition estimates from dual-energy X-ray absorptiometry and stable isotope dilution (2H and 18O) were compared in 61 rhesus monkeys (Macaca mulatta) from the ongoing long-term energy restriction study at the University of Wisconsin. Their average age was 18.9 ± 2.5 y/o. Of the animals, 51% were in the energy restricted group and 38% were females. Although the correlation between methods was highly significant for fat mass (R2 = 0.97, SEE = 0.25 kg or 7.5%, P < 0.0001) and fat-free mass (R2 = 0.98, SEE = 0.29 kg or 3.6%, P < 0.0001), we observed that dual-energy X-ray absorptiometry underestimated fat mass by 0.67 ± 0.26 kg (7.5%, P < 0.0001) and overestimated fat-free mass by 0.57 ± 0.29 kg (20%, P < 0.0001) when compared with isotope dilution. Taken together with data from the literature, the present results emphasize the usefulness of dual-energy X-ray absorptiometry to derive body composition and thus nutritional status in monkeys, but demonstrate the importance of validation experiments for a given DXA model and software.

Original languageEnglish (US)
Pages (from-to)130-138
Number of pages9
JournalJournal of Medical Primatology
Volume34
Issue number3
DOIs
StatePublished - Jun 2005

Keywords

  • Absorptiometry
  • Body composition
  • Stable isotopes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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