Assessment of isoflurane-induced anesthesia in ferrets and rats

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Abstract

Objective - To characterize isoflurane (ISO)-induced anesthesia in ferrets and rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague- Dawley rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague-Dawley rats. Procedure - Ferrets and rats were anesthetized in a similar manner, using ISO in oxygen. Minimum alveolar concentration (MAC) was determined, using the tail-clamp method. Immediately thereafter, assessments were recorded for 0.8, 1.0, 1.5, and 2.0 MAC (order randomized) of ISO. Results - MAC of ISO was (mean ± SEM) 1.74 ± 0.03 and 1.58 ± 0.05% for ferrets and rats, respectively. Mean arterial blood pressure (MAP) was 75.0 ± 4.3 and 107.9 ± 2.7 mm Hg at 0.8 MAC for ferrets and rat, respectively, and decreased in a parallel dose-dependent manner. Respiratory frequency decreased in rats as ISO dose increased; however, respiratory frequency increased in ferrets as ISO dose increased from 0.8 to 1.5 MAC but then decreased at 2.0 MAC. At 0.8 MAC, hypoventilation was much greater in ferrets (Paco2 = 71.4 ± 3.5 mm Hg), compared with rats (Paco2 = 57.7 ± 1.9 mm Hg). In both species, Paco2 progressively increased as anesthetic dose increased. Eyelid aperture of ferrets increased in a dose-dependent manner. Pupil diameter in ferrets and rats increased as ISO dose increased. Conclusions and Clinical Relevance - The MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets consistently and predictably changed in response to changes in anesthetic dose of ISO. Magnitude of respiratory depression was greater in ferrets than rats. Changes in MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets are consistent guides to changes in depth of ISO-induced anesthesia.

Original languageEnglish (US)
Pages (from-to)1577-1583
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume60
Issue number12
StatePublished - Dec 1999

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Ferrets
Isoflurane
isoflurane
ferrets
anesthesia
Anesthesia
rats
Arterial Pressure
dosage
eyelids
Eyelids
blood pressure
respiratory rate
anesthetics
Sprague Dawley Rats
Anesthetics
Hypoventilation

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Assessment of isoflurane-induced anesthesia in ferrets and rats. / Imai, Ayako; Steffey, Eugene; Farver, Thomas B; Ilkiw, Jan.

In: American Journal of Veterinary Research, Vol. 60, No. 12, 12.1999, p. 1577-1583.

Research output: Contribution to journalArticle

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title = "Assessment of isoflurane-induced anesthesia in ferrets and rats",
abstract = "Objective - To characterize isoflurane (ISO)-induced anesthesia in ferrets and rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague- Dawley rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague-Dawley rats. Procedure - Ferrets and rats were anesthetized in a similar manner, using ISO in oxygen. Minimum alveolar concentration (MAC) was determined, using the tail-clamp method. Immediately thereafter, assessments were recorded for 0.8, 1.0, 1.5, and 2.0 MAC (order randomized) of ISO. Results - MAC of ISO was (mean ± SEM) 1.74 ± 0.03 and 1.58 ± 0.05{\%} for ferrets and rats, respectively. Mean arterial blood pressure (MAP) was 75.0 ± 4.3 and 107.9 ± 2.7 mm Hg at 0.8 MAC for ferrets and rat, respectively, and decreased in a parallel dose-dependent manner. Respiratory frequency decreased in rats as ISO dose increased; however, respiratory frequency increased in ferrets as ISO dose increased from 0.8 to 1.5 MAC but then decreased at 2.0 MAC. At 0.8 MAC, hypoventilation was much greater in ferrets (Paco2 = 71.4 ± 3.5 mm Hg), compared with rats (Paco2 = 57.7 ± 1.9 mm Hg). In both species, Paco2 progressively increased as anesthetic dose increased. Eyelid aperture of ferrets increased in a dose-dependent manner. Pupil diameter in ferrets and rats increased as ISO dose increased. Conclusions and Clinical Relevance - The MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets consistently and predictably changed in response to changes in anesthetic dose of ISO. Magnitude of respiratory depression was greater in ferrets than rats. Changes in MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets are consistent guides to changes in depth of ISO-induced anesthesia.",
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N2 - Objective - To characterize isoflurane (ISO)-induced anesthesia in ferrets and rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague- Dawley rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague-Dawley rats. Procedure - Ferrets and rats were anesthetized in a similar manner, using ISO in oxygen. Minimum alveolar concentration (MAC) was determined, using the tail-clamp method. Immediately thereafter, assessments were recorded for 0.8, 1.0, 1.5, and 2.0 MAC (order randomized) of ISO. Results - MAC of ISO was (mean ± SEM) 1.74 ± 0.03 and 1.58 ± 0.05% for ferrets and rats, respectively. Mean arterial blood pressure (MAP) was 75.0 ± 4.3 and 107.9 ± 2.7 mm Hg at 0.8 MAC for ferrets and rat, respectively, and decreased in a parallel dose-dependent manner. Respiratory frequency decreased in rats as ISO dose increased; however, respiratory frequency increased in ferrets as ISO dose increased from 0.8 to 1.5 MAC but then decreased at 2.0 MAC. At 0.8 MAC, hypoventilation was much greater in ferrets (Paco2 = 71.4 ± 3.5 mm Hg), compared with rats (Paco2 = 57.7 ± 1.9 mm Hg). In both species, Paco2 progressively increased as anesthetic dose increased. Eyelid aperture of ferrets increased in a dose-dependent manner. Pupil diameter in ferrets and rats increased as ISO dose increased. Conclusions and Clinical Relevance - The MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets consistently and predictably changed in response to changes in anesthetic dose of ISO. Magnitude of respiratory depression was greater in ferrets than rats. Changes in MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets are consistent guides to changes in depth of ISO-induced anesthesia.

AB - Objective - To characterize isoflurane (ISO)-induced anesthesia in ferrets and rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague- Dawley rats. Animals - 8 ferrets (Mustela putorius furo) and 8 Sprague-Dawley rats. Procedure - Ferrets and rats were anesthetized in a similar manner, using ISO in oxygen. Minimum alveolar concentration (MAC) was determined, using the tail-clamp method. Immediately thereafter, assessments were recorded for 0.8, 1.0, 1.5, and 2.0 MAC (order randomized) of ISO. Results - MAC of ISO was (mean ± SEM) 1.74 ± 0.03 and 1.58 ± 0.05% for ferrets and rats, respectively. Mean arterial blood pressure (MAP) was 75.0 ± 4.3 and 107.9 ± 2.7 mm Hg at 0.8 MAC for ferrets and rat, respectively, and decreased in a parallel dose-dependent manner. Respiratory frequency decreased in rats as ISO dose increased; however, respiratory frequency increased in ferrets as ISO dose increased from 0.8 to 1.5 MAC but then decreased at 2.0 MAC. At 0.8 MAC, hypoventilation was much greater in ferrets (Paco2 = 71.4 ± 3.5 mm Hg), compared with rats (Paco2 = 57.7 ± 1.9 mm Hg). In both species, Paco2 progressively increased as anesthetic dose increased. Eyelid aperture of ferrets increased in a dose-dependent manner. Pupil diameter in ferrets and rats increased as ISO dose increased. Conclusions and Clinical Relevance - The MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets consistently and predictably changed in response to changes in anesthetic dose of ISO. Magnitude of respiratory depression was greater in ferrets than rats. Changes in MAP and Paco2 in ferrets and rats and eyelid aperture in ferrets are consistent guides to changes in depth of ISO-induced anesthesia.

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