Assessment of foveal cone photoreceptors in Stargardt's macular dystrophy using a small dot detection task

Andrew M. Geller, Paul A. Sieving

Research output: Contribution to journalArticlepeer-review

Abstract

We measured frequency-of-seeing curves for tiny (1.125 and 3.375 min arc) stimuli flashed briefly at absolute threshold to estimate the density of foveal cones in normals and in subjects with Stargardt's macular dystrophy. Foveal absolute thresholds for Stargardt's were elevated 1.5 log units over normal. Analysis using Poisson counting statistics indicated that the quantal absorption to stimulate individual cones was normal for Stargardt's but that effective optical density of individual cones was reduced by > 1 log. Numerical density of foveal cones was reduced 1 log unit for Stargardt's patients with acuities of 20 30- 20 100.

Original languageEnglish (US)
Pages (from-to)1509-1524
Number of pages16
JournalVision Research
Volume33
Issue number11
DOIs
StatePublished - Jul 1993
Externally publishedYes

Keywords

  • Absolute threshold
  • Cone
  • Fovea
  • Human
  • Optical density
  • Psychophysics
  • Retina
  • Stargardt's

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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