Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions

A report from the Children's Oncology Group

Carol D. Morris, Lisa A. Teot, Mark L. Bernstein, Neyssa Marina, Mark D. Krailo, Doojduen Villaluna, Katherine A. Janeway, Steven G. Dubois, Richard G. Gorlick, R Randall

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Complete surgical resection of primary tumors is critical for long-term control of high-grade osteosarcoma. Uniform assessment of the extent of surgical resection is important in clinical trials, though the accuracy of this reporting has been poorly studied. Methods We conducted a retrospective cohort study of patients 5-40 years of age with newly diagnosed high-grade resectable osteosarcoma treated as part of the AOST0331 clinical trial at Children's Oncology Group institutions. The extent of surgical resection of the primary tumor was graded as wide or radical by the treating institution. Central assessment of the extent of resection by two orthopedic oncologists was compared with institutional assessment by reviewing pathology and operative reports. Results We included 956 patients who had data available for central review. The extent of resection reported by treating institutions was 536/956 (56%) radical and 420/956 (44%) wide. The extent of resection assessed by central review was 162/956 (17%) radical and 794/956 (83%) wide. The overall discordance rate for the cohort was 43%. Conclusions Institutional reports of radical resection in high-grade osteosarcoma significantly over-estimate the proportion of patients undergoing radical resection. This highlights the need for centralized review and improved accuracy of reporting of the extent of resection.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalJournal of Surgical Oncology
Volume113
Issue number4
DOIs
StatePublished - Mar 15 2016
Externally publishedYes

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Osteosarcoma
Clinical Trials
Orthopedics
Neoplasms
Cohort Studies
Retrospective Studies
Pathology

Keywords

  • cooperative group trial
  • osteosarcoma
  • surgical margins

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions : A report from the Children's Oncology Group. / Morris, Carol D.; Teot, Lisa A.; Bernstein, Mark L.; Marina, Neyssa; Krailo, Mark D.; Villaluna, Doojduen; Janeway, Katherine A.; Dubois, Steven G.; Gorlick, Richard G.; Randall, R.

In: Journal of Surgical Oncology, Vol. 113, No. 4, 15.03.2016, p. 351-354.

Research output: Contribution to journalArticle

Morris, CD, Teot, LA, Bernstein, ML, Marina, N, Krailo, MD, Villaluna, D, Janeway, KA, Dubois, SG, Gorlick, RG & Randall, R 2016, 'Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group', Journal of Surgical Oncology, vol. 113, no. 4, pp. 351-354. https://doi.org/10.1002/jso.24145
Morris, Carol D. ; Teot, Lisa A. ; Bernstein, Mark L. ; Marina, Neyssa ; Krailo, Mark D. ; Villaluna, Doojduen ; Janeway, Katherine A. ; Dubois, Steven G. ; Gorlick, Richard G. ; Randall, R. / Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions : A report from the Children's Oncology Group. In: Journal of Surgical Oncology. 2016 ; Vol. 113, No. 4. pp. 351-354.
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abstract = "Background Complete surgical resection of primary tumors is critical for long-term control of high-grade osteosarcoma. Uniform assessment of the extent of surgical resection is important in clinical trials, though the accuracy of this reporting has been poorly studied. Methods We conducted a retrospective cohort study of patients 5-40 years of age with newly diagnosed high-grade resectable osteosarcoma treated as part of the AOST0331 clinical trial at Children's Oncology Group institutions. The extent of surgical resection of the primary tumor was graded as wide or radical by the treating institution. Central assessment of the extent of resection by two orthopedic oncologists was compared with institutional assessment by reviewing pathology and operative reports. Results We included 956 patients who had data available for central review. The extent of resection reported by treating institutions was 536/956 (56{\%}) radical and 420/956 (44{\%}) wide. The extent of resection assessed by central review was 162/956 (17{\%}) radical and 794/956 (83{\%}) wide. The overall discordance rate for the cohort was 43{\%}. Conclusions Institutional reports of radical resection in high-grade osteosarcoma significantly over-estimate the proportion of patients undergoing radical resection. This highlights the need for centralized review and improved accuracy of reporting of the extent of resection.",
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