TY - JOUR
T1 - Assessment of exposure to pulmonary toxicants
T2 - Use of biological markers
AU - Bond, James A.
AU - Wallace, Lance A.
AU - Osterman-Golkar, Siv
AU - Lucier, George W.
AU - Buckpitt, Alan R
AU - Hendersen, Rogene F.
PY - 1992
Y1 - 1992
N2 - The use of biological markers to determine the extent of prior exposures to a specific chemical and to predict future disease outcome holds great promise. Knowledge of the kinetics of formation and breakdown or clearance used to monitor exposures or to predict adverse health outcomes in a quantitative manner. Also required is more quantitative information on the relationship between the markers and resultant disease. Much of the detailed kinetic information must be obtained from animal studies. The use of PBPK modeling can help to integrate the kinetic data into a useful tool for extrapolation of data from high-to-low dose, between different exposure regimes, and from animal data to expected values in humans.
AB - The use of biological markers to determine the extent of prior exposures to a specific chemical and to predict future disease outcome holds great promise. Knowledge of the kinetics of formation and breakdown or clearance used to monitor exposures or to predict adverse health outcomes in a quantitative manner. Also required is more quantitative information on the relationship between the markers and resultant disease. Much of the detailed kinetic information must be obtained from animal studies. The use of PBPK modeling can help to integrate the kinetic data into a useful tool for extrapolation of data from high-to-low dose, between different exposure regimes, and from animal data to expected values in humans.
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U2 - 10.1016/0272-0590(92)90042-G
DO - 10.1016/0272-0590(92)90042-G
M3 - Article
C2 - 1601216
AN - SCOPUS:0026597427
VL - 18
SP - 161
EP - 174
JO - Toxicological Sciences
JF - Toxicological Sciences
SN - 1096-6080
IS - 2
ER -