Assessment of Canine Pancreas-Specific Lipase and Outcomes in Dogs with Hemodialysis-Dependent Acute Kidney Injury

Research output: Contribution to journalArticle

Abstract

Background: Renal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome. Hypothesis/Objectives: To investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements. Animals: Fifty-three client-owned dogs presented to teaching hospitals between November 2008 and September 2016 that underwent IHD. Methods: Retrospective medical record review from dogs that received IHD for management of AKI and also had a Spec cPL measurement. Association between survival, dialysis-dependency, and Spec cPL measurements was assessed. Results: Forty of 53 (76%) dogs were alive at 30-days and 33/53(62%) had a Spec cPL result ≥400 μg/L. Spec cPL was not significantly different either between surviving (635.5 μg/L, range 29–1,001) and nonsurviving dogs (860 μg/L, range 56–1,001; P = 0.75) or between dialysis-dependent (1,001 μg/L, range 177–1,001) and nondialysis-dependent dogs (520 μg/L, range 29–1,001; P = 0.08). Spec cPL ≥400 μg/L was not significantly associated either with survival (P = 0.74) or dialysis-dependency (P = 0.33). Conclusions and Clinical Importance: Results revealed a high prevalence of Spec cPL ≥400 μg/L in dogs with AKI treated with IHD. No significant associations between Spec cPL and survival or dialysis-dependency in dogs with AKI at 30 days were identified in the current study, however, the latter could be due to lack of power in this study.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
JournalJournal of Veterinary Internal Medicine
Volume32
Issue number2
DOIs
StatePublished - Mar 1 2018

Fingerprint

hemodialysis
Lipase
Acute Kidney Injury
pancreas
Renal Dialysis
Canidae
Pancreas
kidneys
Dogs
dogs
dialysis
Dialysis
pancreatitis
Pancreatitis
Renal Replacement Therapy
Teaching Hospitals
Medical Records
Comorbidity
therapeutics

Keywords

  • Canine specific pancreatic lipase
  • Kidney failure
  • Renal recovery
  • Renal replacement therapy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{559ad4fdb3fc41798a90d583cbf81626,
title = "Assessment of Canine Pancreas-Specific Lipase and Outcomes in Dogs with Hemodialysis-Dependent Acute Kidney Injury",
abstract = "Background: Renal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome. Hypothesis/Objectives: To investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements. Animals: Fifty-three client-owned dogs presented to teaching hospitals between November 2008 and September 2016 that underwent IHD. Methods: Retrospective medical record review from dogs that received IHD for management of AKI and also had a Spec cPL measurement. Association between survival, dialysis-dependency, and Spec cPL measurements was assessed. Results: Forty of 53 (76{\%}) dogs were alive at 30-days and 33/53(62{\%}) had a Spec cPL result ≥400 μg/L. Spec cPL was not significantly different either between surviving (635.5 μg/L, range 29–1,001) and nonsurviving dogs (860 μg/L, range 56–1,001; P = 0.75) or between dialysis-dependent (1,001 μg/L, range 177–1,001) and nondialysis-dependent dogs (520 μg/L, range 29–1,001; P = 0.08). Spec cPL ≥400 μg/L was not significantly associated either with survival (P = 0.74) or dialysis-dependency (P = 0.33). Conclusions and Clinical Importance: Results revealed a high prevalence of Spec cPL ≥400 μg/L in dogs with AKI treated with IHD. No significant associations between Spec cPL and survival or dialysis-dependency in dogs with AKI at 30 days were identified in the current study, however, the latter could be due to lack of power in this study.",
keywords = "Canine specific pancreatic lipase, Kidney failure, Renal recovery, Renal replacement therapy",
author = "K. Takada and Carrie Palm and Epstein, {Steven E} and Cowgill, {Larry D}",
year = "2018",
month = "3",
day = "1",
doi = "10.1111/jvim.15047",
language = "English (US)",
volume = "32",
pages = "722--726",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "2",

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TY - JOUR

T1 - Assessment of Canine Pancreas-Specific Lipase and Outcomes in Dogs with Hemodialysis-Dependent Acute Kidney Injury

AU - Takada, K.

AU - Palm, Carrie

AU - Epstein, Steven E

AU - Cowgill, Larry D

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Renal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome. Hypothesis/Objectives: To investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements. Animals: Fifty-three client-owned dogs presented to teaching hospitals between November 2008 and September 2016 that underwent IHD. Methods: Retrospective medical record review from dogs that received IHD for management of AKI and also had a Spec cPL measurement. Association between survival, dialysis-dependency, and Spec cPL measurements was assessed. Results: Forty of 53 (76%) dogs were alive at 30-days and 33/53(62%) had a Spec cPL result ≥400 μg/L. Spec cPL was not significantly different either between surviving (635.5 μg/L, range 29–1,001) and nonsurviving dogs (860 μg/L, range 56–1,001; P = 0.75) or between dialysis-dependent (1,001 μg/L, range 177–1,001) and nondialysis-dependent dogs (520 μg/L, range 29–1,001; P = 0.08). Spec cPL ≥400 μg/L was not significantly associated either with survival (P = 0.74) or dialysis-dependency (P = 0.33). Conclusions and Clinical Importance: Results revealed a high prevalence of Spec cPL ≥400 μg/L in dogs with AKI treated with IHD. No significant associations between Spec cPL and survival or dialysis-dependency in dogs with AKI at 30 days were identified in the current study, however, the latter could be due to lack of power in this study.

AB - Background: Renal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome. Hypothesis/Objectives: To investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements. Animals: Fifty-three client-owned dogs presented to teaching hospitals between November 2008 and September 2016 that underwent IHD. Methods: Retrospective medical record review from dogs that received IHD for management of AKI and also had a Spec cPL measurement. Association between survival, dialysis-dependency, and Spec cPL measurements was assessed. Results: Forty of 53 (76%) dogs were alive at 30-days and 33/53(62%) had a Spec cPL result ≥400 μg/L. Spec cPL was not significantly different either between surviving (635.5 μg/L, range 29–1,001) and nonsurviving dogs (860 μg/L, range 56–1,001; P = 0.75) or between dialysis-dependent (1,001 μg/L, range 177–1,001) and nondialysis-dependent dogs (520 μg/L, range 29–1,001; P = 0.08). Spec cPL ≥400 μg/L was not significantly associated either with survival (P = 0.74) or dialysis-dependency (P = 0.33). Conclusions and Clinical Importance: Results revealed a high prevalence of Spec cPL ≥400 μg/L in dogs with AKI treated with IHD. No significant associations between Spec cPL and survival or dialysis-dependency in dogs with AKI at 30 days were identified in the current study, however, the latter could be due to lack of power in this study.

KW - Canine specific pancreatic lipase

KW - Kidney failure

KW - Renal recovery

KW - Renal replacement therapy

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U2 - 10.1111/jvim.15047

DO - 10.1111/jvim.15047

M3 - Article

VL - 32

SP - 722

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JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

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