Assessment of body composition in long-term hemodialysis patients: Rationale and methodology

Shubho R. Sarkar, Martin K. Kuhlmann, Resham Khilnani, Fansan Zhu, Steven B. Heymsfield, George Kaysen, Nathan W. Levin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Protein-energy malnutrition is seen in patients with advanced stages of chronic kidney disease (CKD) and is even more pronounced in patients receiving long-term hemodialysis treatment. Both entities have great impact on patient morbidity and mortality. Analysis of body composition is an integral part of nutritional assessment and includes the estimation of muscle, fat, and fat-free mass, as well as the extracellular water compartment. Clinical assessment of these compartments is difficult, and gold-standard methods such as tracer dilution, magnetic resonance imaging, and dual-energy x-ray absorptiometry are expensive, cumbersome, and rarely available. We report an ongoing study of body composition in hemodialysis patients involving deuterium and sodium bromide dilution, total body potassium counting, magnetic resonance imaging, whole-body and segmental bioimpedance spectroscopy, and anthropometry. The goals of the study are (1) to validate bioimpedance technology against gold-standard methods for assessment of the various body compartments, (2) to directly quantify visceral adipose tissue mass, a potential source of cytokine production (adipokines) promoting chronic inflammation, and to study its relation to inflammatory markers, and (3) to directly quantify visceral organ mass and to study its relation to uremia toxin generation as assessed by protein catabolic rate and resting energy expenditure. Preliminary results based on up to 40 hemodialysis patients are reported.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalJournal of Renal Nutrition
Volume15
Issue number1
DOIs
StatePublished - Jan 2005

Fingerprint

hemodialysis
Body Composition
body composition
Renal Dialysis
bioelectrical impedance
magnetic resonance imaging
Gold
gold
Fats
Magnetic Resonance Imaging
adipokines
Protein-Energy Malnutrition
methodology
resting energy expenditure
Anthropometry
Nutrition Assessment
protein energy malnutrition
Adipokines
uremia
nutrition assessment

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Urology
  • Food Science
  • Clinical Neurology

Cite this

Sarkar, S. R., Kuhlmann, M. K., Khilnani, R., Zhu, F., Heymsfield, S. B., Kaysen, G., & Levin, N. W. (2005). Assessment of body composition in long-term hemodialysis patients: Rationale and methodology. Journal of Renal Nutrition, 15(1), 152-158. https://doi.org/10.1053/j.jrn.2004.09.038

Assessment of body composition in long-term hemodialysis patients : Rationale and methodology. / Sarkar, Shubho R.; Kuhlmann, Martin K.; Khilnani, Resham; Zhu, Fansan; Heymsfield, Steven B.; Kaysen, George; Levin, Nathan W.

In: Journal of Renal Nutrition, Vol. 15, No. 1, 01.2005, p. 152-158.

Research output: Contribution to journalArticle

Sarkar, SR, Kuhlmann, MK, Khilnani, R, Zhu, F, Heymsfield, SB, Kaysen, G & Levin, NW 2005, 'Assessment of body composition in long-term hemodialysis patients: Rationale and methodology', Journal of Renal Nutrition, vol. 15, no. 1, pp. 152-158. https://doi.org/10.1053/j.jrn.2004.09.038
Sarkar, Shubho R. ; Kuhlmann, Martin K. ; Khilnani, Resham ; Zhu, Fansan ; Heymsfield, Steven B. ; Kaysen, George ; Levin, Nathan W. / Assessment of body composition in long-term hemodialysis patients : Rationale and methodology. In: Journal of Renal Nutrition. 2005 ; Vol. 15, No. 1. pp. 152-158.
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