Assessment of azinphosmethyl exposure in California peach harvest workers

Stephen A Mccurdy, M. E. Hansen, C. P. Weisskopf, R. L. Lopez, F. Schneider, J. Spencer, J. R. Sanborn, R. I. Krieger, B. W. Wilson, D. F. Goldsmith, Marc B Schenker

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalArchives of Environmental Health
Issue number4
StatePublished - 1994

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health


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