Abstract
We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-296 |
| Number of pages | 8 |
| Journal | Archives of Environmental Health |
| Volume | 49 |
| Issue number | 4 |
| State | Published - 1994 |
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ASJC Scopus subject areas
- Environmental Science(all)
- Environmental Chemistry
- Public Health, Environmental and Occupational Health
Cite this
Assessment of azinphosmethyl exposure in California peach harvest workers. / Mccurdy, Stephen A; Hansen, M. E.; Weisskopf, C. P.; Lopez, R. L.; Schneider, F.; Spencer, J.; Sanborn, J. R.; Krieger, R. I.; Wilson, B. W.; Goldsmith, D. F.; Schenker, Marc B.
In: Archives of Environmental Health, Vol. 49, No. 4, 1994, p. 289-296.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of azinphosmethyl exposure in California peach harvest workers
AU - Mccurdy, Stephen A
AU - Hansen, M. E.
AU - Weisskopf, C. P.
AU - Lopez, R. L.
AU - Schneider, F.
AU - Spencer, J.
AU - Sanborn, J. R.
AU - Krieger, R. I.
AU - Wilson, B. W.
AU - Goldsmith, D. F.
AU - Schenker, Marc B
PY - 1994
Y1 - 1994
N2 - We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.
AB - We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028000556&partnerID=8YFLogxK
M3 - Article
VL - 49
SP - 289
EP - 296
JO - Archives of Environmental and Occupational Health
JF - Archives of Environmental and Occupational Health
SN - 1933-8244
IS - 4
ER -