Assessment of azinphosmethyl exposure in California peach harvest workers

Stephen A Mccurdy, M. E. Hansen, C. P. Weisskopf, R. L. Lopez, F. Schneider, J. Spencer, J. R. Sanborn, R. I. Krieger, B. W. Wilson, D. F. Goldsmith, Marc B Schenker

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Abstract

We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalArchives of Environmental Health
Volume49
Issue number4
StatePublished - 1994

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ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Mccurdy, S. A., Hansen, M. E., Weisskopf, C. P., Lopez, R. L., Schneider, F., Spencer, J., Sanborn, J. R., Krieger, R. I., Wilson, B. W., Goldsmith, D. F., & Schenker, M. B. (1994). Assessment of azinphosmethyl exposure in California peach harvest workers. Archives of Environmental Health, 49(4), 289-296.