Assessment of azinphosmethyl exposure in California peach harvest workers

Stephen A Mccurdy; M. E. Hansen; C. P. Weisskopf; R. L. Lopez; F. Schneider; J. Spencer; J. R. Sanborn; R. I. Krieger; B. W. Wilson; D. F. Goldsmith; Marc B Schenker

Assessment of azinphosmethyl exposure in California peach harvest workers

Stephen A Mccurdy, M. E. Hansen, C. P. Weisskopf, R. L. Lopez, F. Schneider, J. Spencer, J. R. Sanborn, R. I. Krieger, B. W. Wilson, D. F. Goldsmith, Marc B Schenker

Public Health Sciences

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39 Scopus citations

Abstract

We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm². Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.

Original language	English (US)
Pages (from-to)	289-296
Number of pages	8
Journal	Archives of Environmental Health
Volume	49
Issue number	4
State	Published - 1994

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ASJC Scopus subject areas

Environmental Science(all)
Environmental Chemistry
Public Health, Environmental and Occupational Health

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Mccurdy, S. A., Hansen, M. E., Weisskopf, C. P., Lopez, R. L., Schneider, F., Spencer, J., Sanborn, J. R., Krieger, R. I., Wilson, B. W., Goldsmith, D. F., & Schenker, M. B. (1994). Assessment of azinphosmethyl exposure in California peach harvest workers. Archives of Environmental Health, 49(4), 289-296.

Assessment of azinphosmethyl exposure in California peach harvest workers. / Mccurdy, Stephen A; Hansen, M. E.; Weisskopf, C. P.; Lopez, R. L.; Schneider, F.; Spencer, J.; Sanborn, J. R.; Krieger, R. I.; Wilson, B. W.; Goldsmith, D. F.; Schenker, Marc B.

In: Archives of Environmental Health, Vol. 49, No. 4, 1994, p. 289-296.

Research output: Contribution to journal › Article

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abstract = "We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion{\textregistered}). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.",

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N2 - We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.

AB - We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.

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Assessment of azinphosmethyl exposure in California peach harvest workers

Abstract

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