Abstract
We compared measurements of urinary alkylphosphate metabolites and oxime- induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion®). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 μg/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (r = +0.31-+0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (r = -0.77). No significant oxime-induced reactivation was found.
Original language | English (US) |
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Pages (from-to) | 289-296 |
Number of pages | 8 |
Journal | Archives of Environmental Health |
Volume | 49 |
Issue number | 4 |
State | Published - 1994 |
ASJC Scopus subject areas
- Environmental Science(all)
- Environmental Chemistry
- Public Health, Environmental and Occupational Health