Assessment of a Risk-Based Approach for Triaging Mammography Examinations during Periods of Reduced Capacity

Diana L. Miglioretti, Michael C.S. Bissell, Karla Kerlikowske, Diana S.M. Buist, Steven R. Cummings, Louise M. Henderson, Tracy Onega, Ellen S. O'Meara, Garth H. Rauscher, Brian L. Sprague, Anna N.A. Tosteson, Karen J. Wernli, Janie M. Lee, Christoph I. Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Importance: Breast cancer screening, surveillance, and diagnostic imaging services were profoundly limited during the initial phase of the coronavirus disease 2019 (COVID-19) pandemic. Objective: To develop a risk-based strategy for triaging mammograms during periods of decreased capacity. Design, Setting, and Participants: This population-based cohort study used data collected prospectively from mammography examinations performed in 2014 to 2019 at 92 radiology facilities in the Breast Cancer Surveillance Consortium. Participants included individuals undergoing mammography. Data were analyzed from August 10 to November 3, 2020. Exposures: Clinical indication for screening, breast symptoms, personal history of breast cancer, age, time since last mammogram/screening interval, family history of breast cancer, breast density, and history of high-risk breast lesion. Main Outcomes and Measures: Combinations of clinical indication, clinical history, and breast cancer risk factors that subdivided mammograms into risk groups according to their cancer detection rate were identified using classification and regression trees. Results: The cohort included 898415 individuals contributing 1878924 mammograms (mean [SD] age at mammogram, 58.6 [11.2] years) interpreted by 448 radiologists, with 1722820 mammograms in individuals without a personal history of breast cancer and 156104 mammograms in individuals with a history of breast cancer. Most individuals were aged 50 to 69 years at imaging (1113174 mammograms [59.2%]), and 204305 (11.2%) were Black, 206087 (11.3%) were Asian or Pacific Islander, 126677 (7.0%) were Hispanic or Latina, and 40021 (2.2%) were another race/ethnicity or mixed race/ethnicity. Cancer detection rates varied widely based on clinical indication, breast symptoms, personal history of breast cancer, and age. The 12% of mammograms with very high (89.6 [95% CI, 82.3-97.5] to 122.3 [95% CI, 108.1-138.0] cancers detected per 1000 mammograms) or high (36.1 [95% CI, 33.1-39.3] to 47.5 [95% CI, 42.4-53.3] cancers detected per 1000 mammograms) cancer detection rates accounted for 55% of all detected cancers and included mammograms to evaluate an abnormal mammogram or breast lump in individuals of all ages regardless of breast cancer history, to evaluate breast symptoms other than lump in individuals with a breast cancer history or without a history but aged 60 years or older, and for short-interval follow-up in individuals aged 60 years or older without a breast cancer history. The 44.2% of mammograms with very low cancer detection rates accounted for 13.1% of detected cancers and included annual screening mammograms in individuals aged 50 to 69 years (3.8 [95% CI, 3.5-4.1] cancers detected per 1000 mammograms) and all screening mammograms in individuals younger than 50 years regardless of screening interval (2.8 [95% CI, 2.6-3.1] cancers detected per 1000 mammograms). Conclusions and Relevance: In this population-based cohort study, clinical indication and individual risk factors were associated with cancer detection and may be useful for prioritizing mammography in times and settings of decreased capacity.

Original languageEnglish (US)
Article numbere211974
JournalJAMA Network Open
Volume4
Issue number3
DOIs
StatePublished - Mar 25 2021

ASJC Scopus subject areas

  • Medicine(all)

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