Abstract
The present work describes our ongoing efforts towards the creation of nano-scaled ordered arrays of protein/virus covalently attached to site-specific chemical linkers patterned by different nanolithograpy techniques. We will present a new and efficient solid-phase approach for the synthesis of chemically modified long alkyl-thiols. These compounds can be used to introduce chemoselective reacting groups onto gold and silicon-based surfaces. Furthermore, these modified thiols have been used to create nanometric patterns by using different nanolithography techniques. We will show that this patterns can react chemoselectively with proteins and/or virus which have been chemically or recombinantly modified to contain complementary chemical groups at specific positions thus resulting in the oriented attachment of the protein or virus to the surface.
Original language | English (US) |
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Title of host publication | 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 |
Editors | M. Laudon, B. Romanowicz |
Pages | 78-80 |
Number of pages | 3 |
Volume | 1 |
State | Published - 2003 |
Externally published | Yes |
Event | 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States Duration: Feb 23 2003 → Feb 27 2003 |
Other
Other | 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 |
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Country | United States |
City | San Francisco, CA |
Period | 2/23/03 → 2/27/03 |
Keywords
- Chemoselective Attachment
- Cow Pea Mosaic Virus (CPMV)
- Dip Pen Nanolithography
- Protein Arrays
ASJC Scopus subject areas
- Engineering(all)