Aspirin dosing using 15 grain enteric coated tablets

S. Pollet, Richard H White, H. Jang, C. W. Yim, D. Feigal

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 μg/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen. Of 36 participants enrolled, 33 (92%) achieved this goal (mean SA = 224 μg/ml), while in the remaining 3 an initially toxic level fell below the therapeutic range after reducing the dose by 1 tablet/day. Although the relationship between dose (mg/kg) and steady state SA levels was roughly linear (r = 0.74), in some subjects there was a striking incremental change in the SA level when the dose was adjusted. Over 90% of subjects taking a starting dose between 45-60 mg/kg/day achieved a therapeutic level. Thus, antiinflammatory therapy using 15 grain/975 mg enteric coated aspirin given twice daily appears to be feasible.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalJournal of Rheumatology
Volume12
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Fingerprint Dive into the research topics of 'Aspirin dosing using 15 grain enteric coated tablets'. Together they form a unique fingerprint.

  • Cite this

    Pollet, S., White, R. H., Jang, H., Yim, C. W., & Feigal, D. (1985). Aspirin dosing using 15 grain enteric coated tablets. Journal of Rheumatology, 12(2), 337-342.