Aspirin dosing using 15 grain enteric coated tablets

S. Pollet, Richard H White, H. Jang, C. W. Yim, D. Feigal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 μg/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen. Of 36 participants enrolled, 33 (92%) achieved this goal (mean SA = 224 μg/ml), while in the remaining 3 an initially toxic level fell below the therapeutic range after reducing the dose by 1 tablet/day. Although the relationship between dose (mg/kg) and steady state SA levels was roughly linear (r = 0.74), in some subjects there was a striking incremental change in the SA level when the dose was adjusted. Over 90% of subjects taking a starting dose between 45-60 mg/kg/day achieved a therapeutic level. Thus, antiinflammatory therapy using 15 grain/975 mg enteric coated aspirin given twice daily appears to be feasible.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalJournal of Rheumatology
Volume12
Issue number2
StatePublished - 1985

Fingerprint

Enteric-Coated Tablets
Salicylates
Aspirin
Poisons
Therapeutics
Tablets
Arthritis
Anti-Inflammatory Agents

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Pollet, S., White, R. H., Jang, H., Yim, C. W., & Feigal, D. (1985). Aspirin dosing using 15 grain enteric coated tablets. Journal of Rheumatology, 12(2), 337-342.

Aspirin dosing using 15 grain enteric coated tablets. / Pollet, S.; White, Richard H; Jang, H.; Yim, C. W.; Feigal, D.

In: Journal of Rheumatology, Vol. 12, No. 2, 1985, p. 337-342.

Research output: Contribution to journalArticle

Pollet, S, White, RH, Jang, H, Yim, CW & Feigal, D 1985, 'Aspirin dosing using 15 grain enteric coated tablets', Journal of Rheumatology, vol. 12, no. 2, pp. 337-342.
Pollet S, White RH, Jang H, Yim CW, Feigal D. Aspirin dosing using 15 grain enteric coated tablets. Journal of Rheumatology. 1985;12(2):337-342.
Pollet, S. ; White, Richard H ; Jang, H. ; Yim, C. W. ; Feigal, D. / Aspirin dosing using 15 grain enteric coated tablets. In: Journal of Rheumatology. 1985 ; Vol. 12, No. 2. pp. 337-342.
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