Abstract
A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 μg/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen. Of 36 participants enrolled, 33 (92%) achieved this goal (mean SA = 224 μg/ml), while in the remaining 3 an initially toxic level fell below the therapeutic range after reducing the dose by 1 tablet/day. Although the relationship between dose (mg/kg) and steady state SA levels was roughly linear (r = 0.74), in some subjects there was a striking incremental change in the SA level when the dose was adjusted. Over 90% of subjects taking a starting dose between 45-60 mg/kg/day achieved a therapeutic level. Thus, antiinflammatory therapy using 15 grain/975 mg enteric coated aspirin given twice daily appears to be feasible.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 337-342 |
| Number of pages | 6 |
| Journal | Journal of Rheumatology |
| Volume | 12 |
| Issue number | 2 |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Aspirin dosing using 15 grain enteric coated tablets. / Pollet, S.; White, Richard H; Jang, H.; Yim, C. W.; Feigal, D.
In: Journal of Rheumatology, Vol. 12, No. 2, 1985, p. 337-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aspirin dosing using 15 grain enteric coated tablets
AU - Pollet, S.
AU - White, Richard H
AU - Jang, H.
AU - Yim, C. W.
AU - Feigal, D.
PY - 1985
Y1 - 1985
N2 - A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 μg/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen. Of 36 participants enrolled, 33 (92%) achieved this goal (mean SA = 224 μg/ml), while in the remaining 3 an initially toxic level fell below the therapeutic range after reducing the dose by 1 tablet/day. Although the relationship between dose (mg/kg) and steady state SA levels was roughly linear (r = 0.74), in some subjects there was a striking incremental change in the SA level when the dose was adjusted. Over 90% of subjects taking a starting dose between 45-60 mg/kg/day achieved a therapeutic level. Thus, antiinflammatory therapy using 15 grain/975 mg enteric coated aspirin given twice daily appears to be feasible.
AB - A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 μg/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen. Of 36 participants enrolled, 33 (92%) achieved this goal (mean SA = 224 μg/ml), while in the remaining 3 an initially toxic level fell below the therapeutic range after reducing the dose by 1 tablet/day. Although the relationship between dose (mg/kg) and steady state SA levels was roughly linear (r = 0.74), in some subjects there was a striking incremental change in the SA level when the dose was adjusted. Over 90% of subjects taking a starting dose between 45-60 mg/kg/day achieved a therapeutic level. Thus, antiinflammatory therapy using 15 grain/975 mg enteric coated aspirin given twice daily appears to be feasible.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021883968&partnerID=8YFLogxK
M3 - Article
C2 - 4032405
AN - SCOPUS:0021883968
VL - 12
SP - 337
EP - 342
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 2
ER -