Abstract
Aspirin or bile administrated by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion. Histamine H1 receptors can be blocked by conventional antihistamine drugs. The H2 receptors, which mediate gastric acid secretion, are blocked by such thiourea compounds as burimamide and metiamide. Metiamide inhibits the basal-, nocturnal-, and pentagastrin stimulated secretion of gastric acid in gastric and duodenal ulcer patients and in cases of Zollinger-Ellison syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 206-207 |
| Number of pages | 2 |
| Journal | Archives of Pathology and Laboratory Medicine |
| Volume | 101 |
| Issue number | 4 |
| State | Published - 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology
Cite this
Aspirin and bile induced acute erosive gastritis. Its prevention by metiamide therapy. / Mann, Nirmal S; Sachdev, A. J.
In: Archives of Pathology and Laboratory Medicine, Vol. 101, No. 4, 1977, p. 206-207.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aspirin and bile induced acute erosive gastritis. Its prevention by metiamide therapy
AU - Mann, Nirmal S
AU - Sachdev, A. J.
PY - 1977
Y1 - 1977
N2 - Aspirin or bile administrated by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion. Histamine H1 receptors can be blocked by conventional antihistamine drugs. The H2 receptors, which mediate gastric acid secretion, are blocked by such thiourea compounds as burimamide and metiamide. Metiamide inhibits the basal-, nocturnal-, and pentagastrin stimulated secretion of gastric acid in gastric and duodenal ulcer patients and in cases of Zollinger-Ellison syndrome.
AB - Aspirin or bile administrated by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion. Histamine H1 receptors can be blocked by conventional antihistamine drugs. The H2 receptors, which mediate gastric acid secretion, are blocked by such thiourea compounds as burimamide and metiamide. Metiamide inhibits the basal-, nocturnal-, and pentagastrin stimulated secretion of gastric acid in gastric and duodenal ulcer patients and in cases of Zollinger-Ellison syndrome.
UR - http://www.scopus.com/inward/record.url?scp=0017718228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017718228&partnerID=8YFLogxK
M3 - Article
C2 - 576788
AN - SCOPUS:0017718228
VL - 101
SP - 206
EP - 207
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
SN - 0003-9985
IS - 4
ER -