Aspirin and bile induced acute erosive gastritis. Its prevention by metiamide therapy

Nirmal S Mann; A. J. Sachdev

Aspirin and bile induced acute erosive gastritis. Its prevention by metiamide therapy

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Abstract

Aspirin or bile administrated by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H₂ receptor antagonist that is known to inhibit gastric acid secretion. Histamine H₁ receptors can be blocked by conventional antihistamine drugs. The H₂ receptors, which mediate gastric acid secretion, are blocked by such thiourea compounds as burimamide and metiamide. Metiamide inhibits the basal-, nocturnal-, and pentagastrin stimulated secretion of gastric acid in gastric and duodenal ulcer patients and in cases of Zollinger-Ellison syndrome.

Original language	English (US)
Pages (from-to)	206-207
Number of pages	2
Journal	Archives of Pathology and Laboratory Medicine
Volume	101
Issue number	4
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Medical Laboratory Technology

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abstract = "Aspirin or bile administrated by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion. Histamine H1 receptors can be blocked by conventional antihistamine drugs. The H2 receptors, which mediate gastric acid secretion, are blocked by such thiourea compounds as burimamide and metiamide. Metiamide inhibits the basal-, nocturnal-, and pentagastrin stimulated secretion of gastric acid in gastric and duodenal ulcer patients and in cases of Zollinger-Ellison syndrome.",

author = "Mann, {Nirmal S} and Sachdev, {A. J.}",

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AB - Aspirin or bile administrated by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion. Histamine H1 receptors can be blocked by conventional antihistamine drugs. The H2 receptors, which mediate gastric acid secretion, are blocked by such thiourea compounds as burimamide and metiamide. Metiamide inhibits the basal-, nocturnal-, and pentagastrin stimulated secretion of gastric acid in gastric and duodenal ulcer patients and in cases of Zollinger-Ellison syndrome.

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