Aspirin or bile administrated by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion. Histamine H1 receptors can be blocked by conventional antihistamine drugs. The H2 receptors, which mediate gastric acid secretion, are blocked by such thiourea compounds as burimamide and metiamide. Metiamide inhibits the basal-, nocturnal-, and pentagastrin stimulated secretion of gastric acid in gastric and duodenal ulcer patients and in cases of Zollinger-Ellison syndrome.
|Original language||English (US)|
|Number of pages||2|
|Journal||Archives of Pathology and Laboratory Medicine|
|State||Published - 1977|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology