Asian ethnicity and breast cancer subtypes: A study from the California Cancer Registry

Melinda L. Telli, Ellen T. Chang, Allison W. Kurian, Theresa H Keegan, Laura A. McClure, Daphne Lichtensztajn, James M. Ford, Scarlett L. Gomez

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The distribution of breast cancer molecular subtypes has been shown to vary by race/ethnicity, highlighting the importance of host factors in breast tumor biology. We undertook the current analysis to determine population-based distributions of breast cancer subtypes among six ethnic Asian groups in California. We defined immunohistochemical (IHC) surrogates for each breast cancer subtype among Chinese, Japanese, Filipina, Korean, Vietnamese, and South Asian patients diagnosed with incident, primary, invasive breast cancer between 2002 and 2007 in the California Cancer Registry as: hormone receptor-positive (HR+)/HER2- [estrogen receptor-positive (ER+) and/or progesterone receptor-positive (PR+), human epidermal growth factor receptor 2-negative (HER2-)], triple-negative (ER-, PR-, and HER2-), and HER2-positive (ER±, PR±, and HER2+). We calculated frequencies of breast cancer subtypes among Asian ethnic groups and evaluated their associations with clinical and demographic factors. Complete IHC data were available for 8,140 Asian women. Compared to non-Hispanic White women, Korean [odds ratio (OR) = 1.8, 95% confidence interval (CI) = 1.5-2.2], Filipina (OR = 1.3, 95% CI = 1.2-1.5), Vietnamese (OR = 1.3, 95% CI = 1.1-1.6), and Chinese (OR = 1.1, 95% CI = 1.0-1.3) women had a significantly increased risk of being diagnosed with HER2-positive breast cancer subtypes after adjusting for age, stage, grade, socioeconomic status, histology, diagnosis year, nativity, and hospital ownership status. We report a significant ethnic disparity in HER2-positive breast cancer in a large population-based cohort enriched for Asian-Americans. Given the poor prognosis and high treatment costs of HER2-positive breast cancer, our results have implications for healthcare resource utilization, cancer biology, and clinical care.

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalBreast Cancer Research and Treatment
Volume127
Issue number2
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Registries
Breast Neoplasms
Neoplasms
Odds Ratio
Confidence Intervals
Ethnic Groups
Demography
Asian Americans
Ownership
Progesterone Receptors
human ERBB2 protein
Social Class
Estrogen Receptors
Health Care Costs
Histology
Hormones
Delivery of Health Care
Population

Keywords

  • Asian
  • Breast cancer subtypes
  • Ethnicity
  • HER2-positive breast cancer
  • Hormone receptor-positive breast cancer
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Telli, M. L., Chang, E. T., Kurian, A. W., Keegan, T. H., McClure, L. A., Lichtensztajn, D., ... Gomez, S. L. (2011). Asian ethnicity and breast cancer subtypes: A study from the California Cancer Registry. Breast Cancer Research and Treatment, 127(2), 471-478. https://doi.org/10.1007/s10549-010-1173-8

Asian ethnicity and breast cancer subtypes : A study from the California Cancer Registry. / Telli, Melinda L.; Chang, Ellen T.; Kurian, Allison W.; Keegan, Theresa H; McClure, Laura A.; Lichtensztajn, Daphne; Ford, James M.; Gomez, Scarlett L.

In: Breast Cancer Research and Treatment, Vol. 127, No. 2, 06.2011, p. 471-478.

Research output: Contribution to journalArticle

Telli, ML, Chang, ET, Kurian, AW, Keegan, TH, McClure, LA, Lichtensztajn, D, Ford, JM & Gomez, SL 2011, 'Asian ethnicity and breast cancer subtypes: A study from the California Cancer Registry', Breast Cancer Research and Treatment, vol. 127, no. 2, pp. 471-478. https://doi.org/10.1007/s10549-010-1173-8
Telli, Melinda L. ; Chang, Ellen T. ; Kurian, Allison W. ; Keegan, Theresa H ; McClure, Laura A. ; Lichtensztajn, Daphne ; Ford, James M. ; Gomez, Scarlett L. / Asian ethnicity and breast cancer subtypes : A study from the California Cancer Registry. In: Breast Cancer Research and Treatment. 2011 ; Vol. 127, No. 2. pp. 471-478.
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