Ascorbate neurotoxicity in cortical cell culture

Kinya Hisanaga, Stephen M. Sagar, Frank R Sharp

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Ascorbate (vitamin C) is believed to act as a neuromodulator that facilitates the release of neurotransmitters and inhibits neurotransmitter binding to receptors, including dopamine and N-methyl-D-aspartate receptors. Extracellular levels of ascorbate are known to reach the low millimolar range after ischemic brain injury. This study shows that treatment of cultured cortical neurons with micromolar to low millimolar ascorbate first inhibits total protein synthesis and then results in late neuronal death. Astrocytes are much less vulnerable to ascorbate than neurons. Ascorbate may exacerbate neuronal and glial damage after brain ischemia, and it may play a pathological role in other neurological diseases.

Original languageEnglish (US)
Pages (from-to)562-565
Number of pages4
JournalAnnals of Neurology
Issue number5
StatePublished - May 1992
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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