Abstract
Articular cartilage (AC) has no or very low ability of self-repair, and untreated lesions may lead to the development of osteoarthritis. One method that has been proven to result in long-term repair or isolated lesions is autologous chondrocyte transplantation. However, first generation of these cells' implantation has limitations, and introducing new effective cell sources can improve cartilage repair. AC provides a resilient and compliant articulating surface to the bones in diarthrodial joints. It protects the joint by distributing loads applied to it, so preventing potentially damaging stress concentrations on the bone. At the same time it provides a low-friction-bearing surface to enable free movement of the joint. AC may be considered as a visco- or poro-elastic fiber-composite material. Fibrils of predominantly type II collagen provide tensile reinforcing to a highly hydrated proteoglycan gel. The tissue typically comprises 70% water and it is the structuring and retention of this water by the proteoglycans and collagen that is largely responsible for the remarkable ability of the tissue to support compressive loads.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 617-627 |
| Number of pages | 11 |
| Journal | Tissue Engineering - Part B: Reviews |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2010 |
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ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Bioengineering
- Biochemistry
Cite this
Articular cartilage : Structure and regeneration. / Becerra, José; Andrades, José A.; Guerado, Enrique; Zamora-Navas, Plácido; López-Puertas, José M.; Reddi, A Hari.
In: Tissue Engineering - Part B: Reviews, Vol. 16, No. 6, 01.12.2010, p. 617-627.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Articular cartilage
T2 - Structure and regeneration
AU - Becerra, José
AU - Andrades, José A.
AU - Guerado, Enrique
AU - Zamora-Navas, Plácido
AU - López-Puertas, José M.
AU - Reddi, A Hari
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Articular cartilage (AC) has no or very low ability of self-repair, and untreated lesions may lead to the development of osteoarthritis. One method that has been proven to result in long-term repair or isolated lesions is autologous chondrocyte transplantation. However, first generation of these cells' implantation has limitations, and introducing new effective cell sources can improve cartilage repair. AC provides a resilient and compliant articulating surface to the bones in diarthrodial joints. It protects the joint by distributing loads applied to it, so preventing potentially damaging stress concentrations on the bone. At the same time it provides a low-friction-bearing surface to enable free movement of the joint. AC may be considered as a visco- or poro-elastic fiber-composite material. Fibrils of predominantly type II collagen provide tensile reinforcing to a highly hydrated proteoglycan gel. The tissue typically comprises 70% water and it is the structuring and retention of this water by the proteoglycans and collagen that is largely responsible for the remarkable ability of the tissue to support compressive loads.
AB - Articular cartilage (AC) has no or very low ability of self-repair, and untreated lesions may lead to the development of osteoarthritis. One method that has been proven to result in long-term repair or isolated lesions is autologous chondrocyte transplantation. However, first generation of these cells' implantation has limitations, and introducing new effective cell sources can improve cartilage repair. AC provides a resilient and compliant articulating surface to the bones in diarthrodial joints. It protects the joint by distributing loads applied to it, so preventing potentially damaging stress concentrations on the bone. At the same time it provides a low-friction-bearing surface to enable free movement of the joint. AC may be considered as a visco- or poro-elastic fiber-composite material. Fibrils of predominantly type II collagen provide tensile reinforcing to a highly hydrated proteoglycan gel. The tissue typically comprises 70% water and it is the structuring and retention of this water by the proteoglycans and collagen that is largely responsible for the remarkable ability of the tissue to support compressive loads.
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U2 - 10.1089/ten.teb.2010.0191
DO - 10.1089/ten.teb.2010.0191
M3 - Article
VL - 16
SP - 617
EP - 627
JO - Tissue Engineering - Part B: Reviews
JF - Tissue Engineering - Part B: Reviews
SN - 1937-3368
IS - 6
ER -