Articular cartilage

Structure and regeneration

José Becerra, José A. Andrades, Enrique Guerado, Plácido Zamora-Navas, José M. López-Puertas, A Hari Reddi

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Articular cartilage (AC) has no or very low ability of self-repair, and untreated lesions may lead to the development of osteoarthritis. One method that has been proven to result in long-term repair or isolated lesions is autologous chondrocyte transplantation. However, first generation of these cells' implantation has limitations, and introducing new effective cell sources can improve cartilage repair. AC provides a resilient and compliant articulating surface to the bones in diarthrodial joints. It protects the joint by distributing loads applied to it, so preventing potentially damaging stress concentrations on the bone. At the same time it provides a low-friction-bearing surface to enable free movement of the joint. AC may be considered as a visco- or poro-elastic fiber-composite material. Fibrils of predominantly type II collagen provide tensile reinforcing to a highly hydrated proteoglycan gel. The tissue typically comprises 70% water and it is the structuring and retention of this water by the proteoglycans and collagen that is largely responsible for the remarkable ability of the tissue to support compressive loads.

Original languageEnglish (US)
Pages (from-to)617-627
Number of pages11
JournalTissue Engineering - Part B: Reviews
Volume16
Issue number6
DOIs
StatePublished - Dec 1 2010

Fingerprint

Cartilage
Articular Cartilage
Regeneration
Joints
Proteoglycans
Repair
Collagen
Bone and Bones
Bone
Elastic Tissue
Bearings (structural)
Collagen Type II
Friction
Water
Autologous Transplantation
Tissue
Chondrocytes
Osteoarthritis
Gels
Stress concentration

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering
  • Biochemistry

Cite this

Becerra, J., Andrades, J. A., Guerado, E., Zamora-Navas, P., López-Puertas, J. M., & Reddi, A. H. (2010). Articular cartilage: Structure and regeneration. Tissue Engineering - Part B: Reviews, 16(6), 617-627. https://doi.org/10.1089/ten.teb.2010.0191

Articular cartilage : Structure and regeneration. / Becerra, José; Andrades, José A.; Guerado, Enrique; Zamora-Navas, Plácido; López-Puertas, José M.; Reddi, A Hari.

In: Tissue Engineering - Part B: Reviews, Vol. 16, No. 6, 01.12.2010, p. 617-627.

Research output: Contribution to journalArticle

Becerra, J, Andrades, JA, Guerado, E, Zamora-Navas, P, López-Puertas, JM & Reddi, AH 2010, 'Articular cartilage: Structure and regeneration', Tissue Engineering - Part B: Reviews, vol. 16, no. 6, pp. 617-627. https://doi.org/10.1089/ten.teb.2010.0191
Becerra J, Andrades JA, Guerado E, Zamora-Navas P, López-Puertas JM, Reddi AH. Articular cartilage: Structure and regeneration. Tissue Engineering - Part B: Reviews. 2010 Dec 1;16(6):617-627. https://doi.org/10.1089/ten.teb.2010.0191
Becerra, José ; Andrades, José A. ; Guerado, Enrique ; Zamora-Navas, Plácido ; López-Puertas, José M. ; Reddi, A Hari. / Articular cartilage : Structure and regeneration. In: Tissue Engineering - Part B: Reviews. 2010 ; Vol. 16, No. 6. pp. 617-627.
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