Articular cartilage injury and potential remedies

Susanna Chubinskaya, Dominik R Haudenschild, Seth Gasser, James Stannard, Christian Krettek, Joseph Borrelli

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Osteoarthritis affects millions of people worldwide, is associated with joint stiffness and pain, and often causes significant disability and loss of productivity. Osteoarthritis is believed to occur as a result of ordinary "wear and tear" on joints during the course of normal activities of daily living. Posttraumatic osteoarthritis is a particular subset of osteoarthritis that occurs after a joint injury. Developing clinically relevant animal models will allow investigators to delineate the causes of posttraumatic osteoarthritis and develop means to slow or prevent its development after joint injury. Chondroprotectant compounds, which attack the degenerative pathways at a variety of steps, are being developed in an effort to prevent posttraumatic osteoarthritis and offer great promise. Often times, cartilage degradation after joint injury occurs despite our best efforts. When this happens, there are several evolving techniques that offer at least short-term relief from the effects of posttraumatic osteoarthritis. Occasionally, these traumatic lesions are so large that dramatic steps must be taken in an attempt to restore articular congruity and joint stability. Fresh osteochondral allografts have been used in these settings and offer the possibility of joint preservation. For patients presenting with neglected displaced intra-articular fractures that have healed, intra-articular osteotomy techniques are being developed in an effort to restore joint congruity and function. This article reviews the results of a newly developed animal model of posttraumatic osteoarthritis, several promising chondroprotectant compounds, and also cartilage techniques that are used when degenerative cartilage lesions develop after joint injury.

Original languageEnglish (US)
Pages (from-to)S47-S52
JournalJournal of Orthopaedic Trauma
Volume29
DOIs
StatePublished - 2015

Fingerprint

Articular Cartilage
Joints
Osteoarthritis
Wounds and Injuries
Cartilage
Animal Models
Intra-Articular Fractures
Arthralgia
Activities of Daily Living
Osteotomy
Tears
Allografts
Research Personnel

Keywords

  • Articular cartilage
  • Chondroprotectant
  • Fresh osteo-articular allograft
  • Intra-articular osteotomy
  • Microfracture
  • Model
  • Posttraumatic osteoarthritis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Chubinskaya, S., Haudenschild, D. R., Gasser, S., Stannard, J., Krettek, C., & Borrelli, J. (2015). Articular cartilage injury and potential remedies. Journal of Orthopaedic Trauma, 29, S47-S52. https://doi.org/10.1097/BOT.0000000000000462

Articular cartilage injury and potential remedies. / Chubinskaya, Susanna; Haudenschild, Dominik R; Gasser, Seth; Stannard, James; Krettek, Christian; Borrelli, Joseph.

In: Journal of Orthopaedic Trauma, Vol. 29, 2015, p. S47-S52.

Research output: Contribution to journalArticle

Chubinskaya, S, Haudenschild, DR, Gasser, S, Stannard, J, Krettek, C & Borrelli, J 2015, 'Articular cartilage injury and potential remedies', Journal of Orthopaedic Trauma, vol. 29, pp. S47-S52. https://doi.org/10.1097/BOT.0000000000000462
Chubinskaya, Susanna ; Haudenschild, Dominik R ; Gasser, Seth ; Stannard, James ; Krettek, Christian ; Borrelli, Joseph. / Articular cartilage injury and potential remedies. In: Journal of Orthopaedic Trauma. 2015 ; Vol. 29. pp. S47-S52.
@article{11efb1c97be44cb1879f161db3849aa9,
title = "Articular cartilage injury and potential remedies",
abstract = "Osteoarthritis affects millions of people worldwide, is associated with joint stiffness and pain, and often causes significant disability and loss of productivity. Osteoarthritis is believed to occur as a result of ordinary {"}wear and tear{"} on joints during the course of normal activities of daily living. Posttraumatic osteoarthritis is a particular subset of osteoarthritis that occurs after a joint injury. Developing clinically relevant animal models will allow investigators to delineate the causes of posttraumatic osteoarthritis and develop means to slow or prevent its development after joint injury. Chondroprotectant compounds, which attack the degenerative pathways at a variety of steps, are being developed in an effort to prevent posttraumatic osteoarthritis and offer great promise. Often times, cartilage degradation after joint injury occurs despite our best efforts. When this happens, there are several evolving techniques that offer at least short-term relief from the effects of posttraumatic osteoarthritis. Occasionally, these traumatic lesions are so large that dramatic steps must be taken in an attempt to restore articular congruity and joint stability. Fresh osteochondral allografts have been used in these settings and offer the possibility of joint preservation. For patients presenting with neglected displaced intra-articular fractures that have healed, intra-articular osteotomy techniques are being developed in an effort to restore joint congruity and function. This article reviews the results of a newly developed animal model of posttraumatic osteoarthritis, several promising chondroprotectant compounds, and also cartilage techniques that are used when degenerative cartilage lesions develop after joint injury.",
keywords = "Articular cartilage, Chondroprotectant, Fresh osteo-articular allograft, Intra-articular osteotomy, Microfracture, Model, Posttraumatic osteoarthritis",
author = "Susanna Chubinskaya and Haudenschild, {Dominik R} and Seth Gasser and James Stannard and Christian Krettek and Joseph Borrelli",
year = "2015",
doi = "10.1097/BOT.0000000000000462",
language = "English (US)",
volume = "29",
pages = "S47--S52",
journal = "Journal of Orthopaedic Trauma",
issn = "0890-5339",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Articular cartilage injury and potential remedies

AU - Chubinskaya, Susanna

AU - Haudenschild, Dominik R

AU - Gasser, Seth

AU - Stannard, James

AU - Krettek, Christian

AU - Borrelli, Joseph

PY - 2015

Y1 - 2015

N2 - Osteoarthritis affects millions of people worldwide, is associated with joint stiffness and pain, and often causes significant disability and loss of productivity. Osteoarthritis is believed to occur as a result of ordinary "wear and tear" on joints during the course of normal activities of daily living. Posttraumatic osteoarthritis is a particular subset of osteoarthritis that occurs after a joint injury. Developing clinically relevant animal models will allow investigators to delineate the causes of posttraumatic osteoarthritis and develop means to slow or prevent its development after joint injury. Chondroprotectant compounds, which attack the degenerative pathways at a variety of steps, are being developed in an effort to prevent posttraumatic osteoarthritis and offer great promise. Often times, cartilage degradation after joint injury occurs despite our best efforts. When this happens, there are several evolving techniques that offer at least short-term relief from the effects of posttraumatic osteoarthritis. Occasionally, these traumatic lesions are so large that dramatic steps must be taken in an attempt to restore articular congruity and joint stability. Fresh osteochondral allografts have been used in these settings and offer the possibility of joint preservation. For patients presenting with neglected displaced intra-articular fractures that have healed, intra-articular osteotomy techniques are being developed in an effort to restore joint congruity and function. This article reviews the results of a newly developed animal model of posttraumatic osteoarthritis, several promising chondroprotectant compounds, and also cartilage techniques that are used when degenerative cartilage lesions develop after joint injury.

AB - Osteoarthritis affects millions of people worldwide, is associated with joint stiffness and pain, and often causes significant disability and loss of productivity. Osteoarthritis is believed to occur as a result of ordinary "wear and tear" on joints during the course of normal activities of daily living. Posttraumatic osteoarthritis is a particular subset of osteoarthritis that occurs after a joint injury. Developing clinically relevant animal models will allow investigators to delineate the causes of posttraumatic osteoarthritis and develop means to slow or prevent its development after joint injury. Chondroprotectant compounds, which attack the degenerative pathways at a variety of steps, are being developed in an effort to prevent posttraumatic osteoarthritis and offer great promise. Often times, cartilage degradation after joint injury occurs despite our best efforts. When this happens, there are several evolving techniques that offer at least short-term relief from the effects of posttraumatic osteoarthritis. Occasionally, these traumatic lesions are so large that dramatic steps must be taken in an attempt to restore articular congruity and joint stability. Fresh osteochondral allografts have been used in these settings and offer the possibility of joint preservation. For patients presenting with neglected displaced intra-articular fractures that have healed, intra-articular osteotomy techniques are being developed in an effort to restore joint congruity and function. This article reviews the results of a newly developed animal model of posttraumatic osteoarthritis, several promising chondroprotectant compounds, and also cartilage techniques that are used when degenerative cartilage lesions develop after joint injury.

KW - Articular cartilage

KW - Chondroprotectant

KW - Fresh osteo-articular allograft

KW - Intra-articular osteotomy

KW - Microfracture

KW - Model

KW - Posttraumatic osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=84948669444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948669444&partnerID=8YFLogxK

U2 - 10.1097/BOT.0000000000000462

DO - 10.1097/BOT.0000000000000462

M3 - Article

VL - 29

SP - S47-S52

JO - Journal of Orthopaedic Trauma

JF - Journal of Orthopaedic Trauma

SN - 0890-5339

ER -