Arsenic tissue concentration of immature mice one hour after oral exposure to gold mine tailings

Mari S. Golub, Carl L Keen, Joel F. Commisso, Charles B. Salocks, T. R. Hathaway

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A potentially high bioavailability of arsenic in gold mine tailings from a site in northern California has been suggested by solubility studies. To help address this issue, an in vivo dosing study was conducted using 12-day-old Swiss Webster mouse pups (n = 8/group). A sample of size-fractionated fractionated mine tailings from the site (<20 μm particle size, 691 μg g-1 arsenic) was prepared as an aqueous suspension and administered by gavage in a volume that provided 4 mg As/kg body weight. The control group received the same volume of a commercial soil (1 μg g-1 As) of similar particle size (<60 μm). No mortality or toxic signs were noted in either group. Tissue samples were collected 1 h after gavage, freeze-dried, microwave-digested and analysed for arsenic by ICP/MS (detection limit 2 ng As g-1 dry weight). Arsenic concentrations (ng As g-1 dry weight) in tissues from the pups who received mine tailings were significantly higher than in control tissues. The mean elevation in arsenic concentration was highest in the liver (3364% of control, p < 0.0001), followed by blood (818% of control, p < 0.0001), skin (207% of control, p = 0.07), and brain (143% of control, p < 0.0001). The carcass arsenic concentration (excluding the GI tract, liver, brain and skin) was 138% of control (p = 0.02). The data indicate uptake of arsenic from weathered mine tailings by the immature mouse pups after oral exposure.

Original languageEnglish (US)
Pages (from-to)199-209
Number of pages11
JournalEnvironmental Geochemistry and Health
Volume21
Issue number3
DOIs
StatePublished - 1999

Keywords

  • Arsenic mine tailings
  • Bioavailability
  • Development
  • ICP/MS
  • Mice

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Science(all)
  • Environmental Chemistry
  • Water Science and Technology
  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Arsenic tissue concentration of immature mice one hour after oral exposure to gold mine tailings'. Together they form a unique fingerprint.

  • Cite this