Arsenic exposure from drinking water and birth weight

Claudia Hopenhayn, Catterina Ferreccio, Steven R. Browning, Bin Huang, Cecilia Peralta, Herman Gibb, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Background: Arsenic exposures from drinking water increase the risk of various cancers and noncancer health endpoints. Limited evidence suggests that arsenic may have adverse human reproductive effects. We investigated the association between drinking water arsenic exposure and fetal growth, as manifest in birth weight. Methods: We conducted a prospective cohort study in two Chilean cities with contrasting drinking water arsenic levels: Antofagasta (40 μg/L) and Valparaiso (<1 μg/L). Study subjects completed in-depth interviews and provided urine samples for exposure analysis. We obtained pregnancy and birth information from medical records. The birth weight analysis was restricted to liveborn, singleton infants born between December 1998 and February 2000. Results: The final study group consisted of 424 infants from Antofagasta and 420 from Valparaiso. After controlling for confounders, results of the multivariable analysis indicated that Antofagasta infants had lower mean birth weight (-57 g; 95% confidence interval = -123 to 9). Conclusion: This study suggests that moderate arsenic exposures from drinking water (<50 μg/L) during pregnancy are associated with reduction in birth weight, similar in magnitude to that resulting from other environmental exposures such as environmental tobacco smoke and benzene.

Original languageEnglish (US)
Pages (from-to)593-602
Number of pages10
JournalEpidemiology
Volume14
Issue number5
DOIs
StatePublished - Sep 2003

Fingerprint

Arsenic
Birth Weight
Drinking Water
Pregnancy
Environmental Exposure
Fetal Development
Benzene
Smoke
Tobacco
Medical Records
Cohort Studies
Urine
Parturition
Prospective Studies
Confidence Intervals
Interviews
Health
Neoplasms

Keywords

  • Arsenic
  • Birth weight
  • Drinking water
  • Environmental exposure
  • Reproductive effects

ASJC Scopus subject areas

  • Epidemiology

Cite this

Hopenhayn, C., Ferreccio, C., Browning, S. R., Huang, B., Peralta, C., Gibb, H., & Hertz-Picciotto, I. (2003). Arsenic exposure from drinking water and birth weight. Epidemiology, 14(5), 593-602. https://doi.org/10.1097/01.ede.0000072104.65240.69

Arsenic exposure from drinking water and birth weight. / Hopenhayn, Claudia; Ferreccio, Catterina; Browning, Steven R.; Huang, Bin; Peralta, Cecilia; Gibb, Herman; Hertz-Picciotto, Irva.

In: Epidemiology, Vol. 14, No. 5, 09.2003, p. 593-602.

Research output: Contribution to journalArticle

Hopenhayn, C, Ferreccio, C, Browning, SR, Huang, B, Peralta, C, Gibb, H & Hertz-Picciotto, I 2003, 'Arsenic exposure from drinking water and birth weight', Epidemiology, vol. 14, no. 5, pp. 593-602. https://doi.org/10.1097/01.ede.0000072104.65240.69
Hopenhayn C, Ferreccio C, Browning SR, Huang B, Peralta C, Gibb H et al. Arsenic exposure from drinking water and birth weight. Epidemiology. 2003 Sep;14(5):593-602. https://doi.org/10.1097/01.ede.0000072104.65240.69
Hopenhayn, Claudia ; Ferreccio, Catterina ; Browning, Steven R. ; Huang, Bin ; Peralta, Cecilia ; Gibb, Herman ; Hertz-Picciotto, Irva. / Arsenic exposure from drinking water and birth weight. In: Epidemiology. 2003 ; Vol. 14, No. 5. pp. 593-602.
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