Arrhythmogenic transient dynamics in cardiac myocytes

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Cardiac action potential alternans and early afterdepolarizations (EADs) are linked to cardiac arrhythmias. Periodic action potentials (period 1) in healthy conditions bifurcate to other states such as period 2 or chaos when alternans or EADs occur in pathological conditions. The mechanisms of alternans and EADs have been extensively studied under steady-state conditions, but lethal arrhythmias often occur during the transition between steady states. Why arrhythmias tend to develop during the transition is unclear. We used low-dimensional mathematical models to analyze dynamical mechanisms of transient alternans and EADs. We show that depending on the route from one state to another, action potential alternans and EADs may occur during the transition between two periodic steady states. The route taken depends on the time course of external perturbations or intrinsic signaling, such as β-adrenergic stimulation, which regulate cardiac calcium and potassium currents with differential kinetics.

Original languageEnglish (US)
Pages (from-to)1391-1397
Number of pages7
JournalBiophysical Journal
Volume106
Issue number6
DOIs
StatePublished - Mar 18 2014

ASJC Scopus subject areas

  • Biophysics
  • Medicine(all)

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