Arresting epileptogenesis: The current challenge

Research output: Chapter in Book/Report/Conference proceedingChapter


Although we have long sought treatments that fall under the rubric of “antiepileptic” (or “anticonvulsant”), attention has now shifted to the concept of antiepileptogenesis. Past neglect of this issue has been due largely to a general lack of understanding about the processes of epileptogenesis and thus a practical inability to develop measures that would be effective antiepileptogenic treatments. Our increasing insights into seizure mechanisms and the brain changes that may precede the emergence of an epileptic state have now made it possible to consider seriously the possibility that we may be able to arrest epileptogenesis-that is, actually abort (or at least interfere with) the processes by which a relatively normal brain becomes capable of generating spontaneous, repeated seizures. This more ambitious clinical goal involves focusing on the implementation of treatments that will not only prevent seizure occurrence but also produce a “cure,” so the individual being treated no longer has an epileptic condition. As is the case for many medical conditions, the most effective treatment or cure may lie in prevention. As epileptologists, we would therefore like to develop procedures that stop the epileptogenic process before it becomes a chronic disease state. Antiepileptogenesis is not just a conceptual endpoint but a real and important clinical goal.

Original languageEnglish (US)
Title of host publicationEpilepsy
Subtitle of host publicationMechanisms, Models, and Translational Perspectives
PublisherCRC Press
Number of pages17
ISBN (Electronic)9781420085600
ISBN (Print)9781420085594
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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