Aromatase distribution in the monkey temporal neocortex and hippocampus

Josue G. Yague, Athena Ching Jung Wang, William G M Janssen, Patrick R. Hof, Luis M. Garcia-Segura, Iñigo Azcoitia, John Morrison

Research output: Contribution to journalArticle

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Abstract

Numerous studies have shown that neuronal plasticity in the hippocampus and neocortex is regulated by estrogen and that aromatase, the key enzyme for estrogen biosynthesis, is present in cerebral cortex. Although the expression pattern of aromatase mRNA has been described in the monkey brain, its precise cellular distribution has not been determined. In addition, the degree to which neuronal aromatase is affected by gonadal estrogen has not been investigated. In this study, we examined the immunohistochemical distribution of aromatase in young ovariectomized female rhesus monkeys with or without long-term cyclic estradiol treatment. Both experimental groups showed that aromatase is localized in a large population of CA1-3 pyramidal cells, in granule cells of the dentate gyrus and in some interneurons in which it was co-expressed with the calcium-binding proteins calbindin, calretinin, and parvalbumin. Moreover, numerous pyramidal cells were immunoreactive for aromatase in the neocortex, whereas only small subpopulations of neocortical interneurons were immunoreactive for aromatase. The widespread expression of the protein in a large neuronal population suggests that local intraneuroral estrogen synthesis may contribute to estrogen-induced synaptic plasticity in monkey hippocampus and neocortex of female rhesus monkeys. In addition, the apparent absence of obvious differences in aromatase distribution between the two experimental groups suggests that these localization patterns are not dependent on plasma estradiol levels.

Original languageEnglish (US)
Pages (from-to)115-127
Number of pages13
JournalBrain Research
Volume1209
DOIs
StatePublished - May 13 2008
Externally publishedYes

Fingerprint

Aromatase
Neocortex
Haplorhini
Hippocampus
Estrogens
Neuronal Plasticity
Pyramidal Cells
Interneurons
Macaca mulatta
Estradiol
Calbindin 2
Calbindins
Parvalbumins
Calcium-Binding Proteins
Dentate Gyrus
Cerebral Cortex
Population
Messenger RNA
Brain
Enzymes

Keywords

  • Aromatase
  • Estrogen
  • Hippocampus
  • Interneuron
  • Neocortex
  • Pyramidal cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Yague, J. G., Wang, A. C. J., Janssen, W. G. M., Hof, P. R., Garcia-Segura, L. M., Azcoitia, I., & Morrison, J. (2008). Aromatase distribution in the monkey temporal neocortex and hippocampus. Brain Research, 1209, 115-127. https://doi.org/10.1016/j.brainres.2008.02.061

Aromatase distribution in the monkey temporal neocortex and hippocampus. / Yague, Josue G.; Wang, Athena Ching Jung; Janssen, William G M; Hof, Patrick R.; Garcia-Segura, Luis M.; Azcoitia, Iñigo; Morrison, John.

In: Brain Research, Vol. 1209, 13.05.2008, p. 115-127.

Research output: Contribution to journalArticle

Yague, JG, Wang, ACJ, Janssen, WGM, Hof, PR, Garcia-Segura, LM, Azcoitia, I & Morrison, J 2008, 'Aromatase distribution in the monkey temporal neocortex and hippocampus', Brain Research, vol. 1209, pp. 115-127. https://doi.org/10.1016/j.brainres.2008.02.061
Yague JG, Wang ACJ, Janssen WGM, Hof PR, Garcia-Segura LM, Azcoitia I et al. Aromatase distribution in the monkey temporal neocortex and hippocampus. Brain Research. 2008 May 13;1209:115-127. https://doi.org/10.1016/j.brainres.2008.02.061
Yague, Josue G. ; Wang, Athena Ching Jung ; Janssen, William G M ; Hof, Patrick R. ; Garcia-Segura, Luis M. ; Azcoitia, Iñigo ; Morrison, John. / Aromatase distribution in the monkey temporal neocortex and hippocampus. In: Brain Research. 2008 ; Vol. 1209. pp. 115-127.
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