Argonaute and argonaute-bound small RNAs in stem cells

Lihong Zhai, Lin Wang, Feng Teng, Lanting Zhou, Wenjing Zhang, Juan Xiao, Ying Liu, Wenbin Deng

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals. This review article highlights recent progress on how AGO proteins and AGO-bound small RNAs regulate the self-renewal and differentiation of distinct stem cell types, including pluripotent, germline, somatic, and cancer stem cells.

Original languageEnglish (US)
Article number208
JournalInternational Journal of Molecular Sciences
Volume17
Issue number2
DOIs
StatePublished - Feb 4 2016

Keywords

  • Argonaute
  • Piwi
  • Small RNAs
  • Stem cells

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

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