The acute insulin response to a 5 g pulse of arginine monohydrochloride was studied in 10 patients with non-insulin-dependent diabetes in the young (NIDDY) and 10 age-, weight- and sex-matched control subjects. All diabetics belonged to families in which non-insulin-dependent diabetes was tramsmitted through 3 generations. Mean peak insulin responses were similar in both groups (84.1 ± 10.6; 68.2 ± 8 μU/ml, p > 0.5). However, it is well known that hyperglycaemia accentuates the insulin response to non-glucose stimuli. To test this hypothesis, 5 of the diabetics were subjected to an intravenous insulin tolerance test, prior to the administration of the arginine pulse. At this lowered glucose level, the β-cell secretory response was significantly decreased in the diabetics (C-peptide peak responses 2.5 ± 0.3 vs 4.4 ± 0.7 ng/ml, p < 0.02). Thus it can be concluded that hyperglycaemia enhances the insulin secretory response to non-glucose stimuli and that following correction of the hyperglycaemia patients with NIDDY have an attenuated insulinaemic response.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 1986|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine