Arginine augments neither albuminuria nor albumin synthesis caused by high-protein diets in nephrosis

George Kaysen, Victor I. Martin, Harbin Jones

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Dietary protein independently modulates albuminuria (UAlbV) and albumin synthesis (AlbSyn) in nephrotic rats. While some amino acids are without effect on renal hemodynamics, arginine (Arg) augments renal blood flow and glomerular filtration rate, increases AlbSyn in tissue culture and isolated perfused livers, and could be one specific amino acid causing both decreased glomerular permselectivity and increased AlbSyn. Nephrotic rats were fed 10% casein (LP); 30% casein (HP); 30% casein with the inhibitor of nitric oxide (NO) synthesis Nωnitro-L-arginine methyl ester (HP + L-NAME); 10% casein supplemented with Arg and amino acids that are Arg precursors of or are derived from Arg (proline, glutamate, and aspartate) in an amount in the increment between 10 and 30% casein (ArgAA); ArgAA supplemented with NH4 acetate to provide a diet isonitrogenous to 30% casein (ArgAA + NH4); or 10% casein plus an incomplete mixture of amino acids (Inc) containing the increment in histidine, phenylalanine, tryptophan, tyrosine, lysine, glycine, alanine, serine, threonine, cysteine, and methionine provided when the diet was changed from 10 to 30% casein. UAlbV increased significantly in HP and by a significantly greater amount in HP + L-NAME, but did not change in LP, ArgAA, or ArgAA + NH4. UAlbV tended to increase in Inc, was significantly greater than in LP or in ArgAA + NH4, but less than in HP. AlbSyn ([3H]phenylalanine incorporation) was no different in Inc than in HP, and was significantly greater than in either ArgAA + NH4 or LP. Increased AlbSyn results from increased ingestion of one or more of amino acids in Inc, but not from Arg or its precursors or products or from total dietary nitrogen. Increased UAlbV may require eating a more complete group of amino acids than those contained in Inc. That blockade of NO generation with L-NAME worsens UAlbV suggests that NO may impede changes in glomerular permselectivity when dietary Arg is increased.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Issue number5 32-5
StatePublished - Nov 1992


  • Dietary protein
  • Endothelium-derived relaxation factor
  • Glomerular filtration
  • Nitric oxide
  • Permselectivity
  • Protein synthesis
  • Proteinuria

ASJC Scopus subject areas

  • Physiology


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