Abstract
Background Serum arginase levels have been shown to be elevated in conditions, such as trauma, cancer, chronic wounds, pregnancy, and diabetes. This also has been found to be true in atopic diseases, such as asthma and allergic rhinitis. Objective To study arginase activity in patients with atopic dermatitis (AD). Methods In this pilot study, arginase activity levels in 15 pediatric patients with AD were compared with those in controls to determine whether arginase levels in AD are altered as in patients with other atopic diseases. Results In contrast to the other diseases studied, arginase activity was found to be decreased in granulocytes and in the plasma of patients with AD compared with controls. This finding was coupled with a trend toward higher L-arginine plasma levels. Conclusion In AD, a different mechanism of arginine metabolism seems to be stimulated, leading to the formation of nitric oxide pathway components causing suppression of the arginase pathway and impairment in skin hydration, collagen synthesis, and wound healing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 271-275 |
| Number of pages | 5 |
| Journal | Annals of Allergy, Asthma and Immunology |
| Volume | 113 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Pulmonary and Respiratory Medicine
Cite this
Arginase i levels are decreased in the plasma of pediatric patients with atopic dermatitis. / Dimitriades, Victoria; Rodriguez, Paulo C.; Zabaleta, Jovanny; Ochoa, Augusto C.
In: Annals of Allergy, Asthma and Immunology, Vol. 113, No. 3, 01.01.2014, p. 271-275.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Arginase i levels are decreased in the plasma of pediatric patients with atopic dermatitis
AU - Dimitriades, Victoria
AU - Rodriguez, Paulo C.
AU - Zabaleta, Jovanny
AU - Ochoa, Augusto C.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background Serum arginase levels have been shown to be elevated in conditions, such as trauma, cancer, chronic wounds, pregnancy, and diabetes. This also has been found to be true in atopic diseases, such as asthma and allergic rhinitis. Objective To study arginase activity in patients with atopic dermatitis (AD). Methods In this pilot study, arginase activity levels in 15 pediatric patients with AD were compared with those in controls to determine whether arginase levels in AD are altered as in patients with other atopic diseases. Results In contrast to the other diseases studied, arginase activity was found to be decreased in granulocytes and in the plasma of patients with AD compared with controls. This finding was coupled with a trend toward higher L-arginine plasma levels. Conclusion In AD, a different mechanism of arginine metabolism seems to be stimulated, leading to the formation of nitric oxide pathway components causing suppression of the arginase pathway and impairment in skin hydration, collagen synthesis, and wound healing.
AB - Background Serum arginase levels have been shown to be elevated in conditions, such as trauma, cancer, chronic wounds, pregnancy, and diabetes. This also has been found to be true in atopic diseases, such as asthma and allergic rhinitis. Objective To study arginase activity in patients with atopic dermatitis (AD). Methods In this pilot study, arginase activity levels in 15 pediatric patients with AD were compared with those in controls to determine whether arginase levels in AD are altered as in patients with other atopic diseases. Results In contrast to the other diseases studied, arginase activity was found to be decreased in granulocytes and in the plasma of patients with AD compared with controls. This finding was coupled with a trend toward higher L-arginine plasma levels. Conclusion In AD, a different mechanism of arginine metabolism seems to be stimulated, leading to the formation of nitric oxide pathway components causing suppression of the arginase pathway and impairment in skin hydration, collagen synthesis, and wound healing.
UR - http://www.scopus.com/inward/record.url?scp=84908125801&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908125801&partnerID=8YFLogxK
U2 - 10.1016/j.anai.2014.06.010
DO - 10.1016/j.anai.2014.06.010
M3 - Article
VL - 113
SP - 271
EP - 275
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
SN - 1081-1206
IS - 3
ER -