Area postrema-induced inhibition of the exercise presser reflex

Stefanie Bonigut, Ann C. Bonham, Charles L Stebbins

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The exercise pressor reflex is opposed by the arterial baroreflex, and circulating peptides may act in the area postrema to enhance this inhibition. Therefore, we tested the hypothesis that the area postrema exerts an inhibitory effect on this reflex. Consequently, in six α-chloralose- anesthetized cats, blood pressure and heart rate responses to 30 s of electrically stimulated hindlimb contraction were compared before and after thermal coagulation of the area postrema. In six other cats, the same contraction induced cardiovascular responses were assessed before and after chemical lesion of the area postrema using kainic acid (214 ± 9 nl, 2.5-5 mM). Thermal lesion of the area postrema augmented blood pressure and heart rate responses to contraction from 29 ± 5 to 47 ± 7 mmHg (P < 0.05) and from 8 ± 2 to 14 ± 2 beats/min (P < 0.05), respectively. Chemical lesion of the area postrema enhanced contraction-evoked blood pressure (30 ± 7 vs. 47 ± 6 mmHg, P < 0.05) and heart rate (12 ± 4 vs. 17 ± 4 beats/min, P < 0.05) responses. These data suggest that the area postrema attenuates the exercise presser reflex, possibly through the actions of circulating peptides on baroreflex function.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume272
Issue number4 41-4
StatePublished - 1997

Fingerprint

Area Postrema
Reflex
Baroreflex
Heart Rate
Blood Pressure
Cats
Hot Temperature
Chloralose
Peptides
Kainic Acid
Hindlimb
Inhibition (Psychology)

Keywords

  • arginine vasopressin
  • kainic acid

ASJC Scopus subject areas

  • Physiology

Cite this

Area postrema-induced inhibition of the exercise presser reflex. / Bonigut, Stefanie; Bonham, Ann C.; Stebbins, Charles L.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 272, No. 4 41-4, 1997.

Research output: Contribution to journalArticle

Bonigut, Stefanie ; Bonham, Ann C. ; Stebbins, Charles L. / Area postrema-induced inhibition of the exercise presser reflex. In: American Journal of Physiology - Heart and Circulatory Physiology. 1997 ; Vol. 272, No. 4 41-4.
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