Are Underlying Assumptions of Current Animal Models of Human Stroke Correct: From STAIRs to High Hurdles?

Renée J. Turner, Glen C. Jickling, Frank R Sharp

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Animal models of acute ischemic stroke have been criticized for failing to translate to human stroke. Nevertheless, animal models are necessary to improve our understanding of stroke pathophysiology and to guide the development of new stroke therapies. The rabbit embolic clot model is one animal model that has led to an effective therapy in human acute ischemic stroke, namely tissue plasminogen activator (tPA). We propose that potential compounds that demonstrate efficacy in non-rabbit animal models of acute ischemic stroke should also be tested in the rabbit embolic blood clot model and, where appropriate, compared to tPA prior to investigation in humans. Furthermore, the use of anesthesia needs to be considered as a major confounder in animal models of acute ischemic stroke, and death should be included as an outcome measure in animal stroke studies. These steps, along with the current STAIRs recommendations, may improve the successful translation of experimental therapies to clinical stroke treatments.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalTranslational Stroke Research
Volume2
Issue number2
DOIs
StatePublished - Jun 2011

Fingerprint

Animal Models
Stroke
Tissue Plasminogen Activator
Rabbits
Investigational Therapies
Thrombosis
Therapeutics
Anesthesia
Outcome Assessment (Health Care)

Keywords

  • Animal models
  • Cerebral ischemia
  • Neuroprotection
  • Rabbit
  • Stroke
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Are Underlying Assumptions of Current Animal Models of Human Stroke Correct : From STAIRs to High Hurdles? / Turner, Renée J.; Jickling, Glen C.; Sharp, Frank R.

In: Translational Stroke Research, Vol. 2, No. 2, 06.2011, p. 138-143.

Research output: Contribution to journalArticle

@article{a0eccab83c394cbc9c302f87963866ee,
title = "Are Underlying Assumptions of Current Animal Models of Human Stroke Correct: From STAIRs to High Hurdles?",
abstract = "Animal models of acute ischemic stroke have been criticized for failing to translate to human stroke. Nevertheless, animal models are necessary to improve our understanding of stroke pathophysiology and to guide the development of new stroke therapies. The rabbit embolic clot model is one animal model that has led to an effective therapy in human acute ischemic stroke, namely tissue plasminogen activator (tPA). We propose that potential compounds that demonstrate efficacy in non-rabbit animal models of acute ischemic stroke should also be tested in the rabbit embolic blood clot model and, where appropriate, compared to tPA prior to investigation in humans. Furthermore, the use of anesthesia needs to be considered as a major confounder in animal models of acute ischemic stroke, and death should be included as an outcome measure in animal stroke studies. These steps, along with the current STAIRs recommendations, may improve the successful translation of experimental therapies to clinical stroke treatments.",
keywords = "Animal models, Cerebral ischemia, Neuroprotection, Rabbit, Stroke, Tissue plasminogen activator",
author = "Turner, {Ren{\'e}e J.} and Jickling, {Glen C.} and Sharp, {Frank R}",
year = "2011",
month = "6",
doi = "10.1007/s12975-011-0067-3",
language = "English (US)",
volume = "2",
pages = "138--143",
journal = "Translational Stroke Research",
issn = "1868-4483",
publisher = "Springer US",
number = "2",

}

TY - JOUR

T1 - Are Underlying Assumptions of Current Animal Models of Human Stroke Correct

T2 - From STAIRs to High Hurdles?

AU - Turner, Renée J.

AU - Jickling, Glen C.

AU - Sharp, Frank R

PY - 2011/6

Y1 - 2011/6

N2 - Animal models of acute ischemic stroke have been criticized for failing to translate to human stroke. Nevertheless, animal models are necessary to improve our understanding of stroke pathophysiology and to guide the development of new stroke therapies. The rabbit embolic clot model is one animal model that has led to an effective therapy in human acute ischemic stroke, namely tissue plasminogen activator (tPA). We propose that potential compounds that demonstrate efficacy in non-rabbit animal models of acute ischemic stroke should also be tested in the rabbit embolic blood clot model and, where appropriate, compared to tPA prior to investigation in humans. Furthermore, the use of anesthesia needs to be considered as a major confounder in animal models of acute ischemic stroke, and death should be included as an outcome measure in animal stroke studies. These steps, along with the current STAIRs recommendations, may improve the successful translation of experimental therapies to clinical stroke treatments.

AB - Animal models of acute ischemic stroke have been criticized for failing to translate to human stroke. Nevertheless, animal models are necessary to improve our understanding of stroke pathophysiology and to guide the development of new stroke therapies. The rabbit embolic clot model is one animal model that has led to an effective therapy in human acute ischemic stroke, namely tissue plasminogen activator (tPA). We propose that potential compounds that demonstrate efficacy in non-rabbit animal models of acute ischemic stroke should also be tested in the rabbit embolic blood clot model and, where appropriate, compared to tPA prior to investigation in humans. Furthermore, the use of anesthesia needs to be considered as a major confounder in animal models of acute ischemic stroke, and death should be included as an outcome measure in animal stroke studies. These steps, along with the current STAIRs recommendations, may improve the successful translation of experimental therapies to clinical stroke treatments.

KW - Animal models

KW - Cerebral ischemia

KW - Neuroprotection

KW - Rabbit

KW - Stroke

KW - Tissue plasminogen activator

UR - http://www.scopus.com/inward/record.url?scp=79955725794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955725794&partnerID=8YFLogxK

U2 - 10.1007/s12975-011-0067-3

DO - 10.1007/s12975-011-0067-3

M3 - Article

C2 - 21654913

AN - SCOPUS:79955725794

VL - 2

SP - 138

EP - 143

JO - Translational Stroke Research

JF - Translational Stroke Research

SN - 1868-4483

IS - 2

ER -