Are hepatocellular carcinoma patients more likely to receive liver resection in regions with longer transplant wait times?

Jamie Anderson, A. W. Hemming, D. C. Chang, M. A. Talamini, K. L. Mekeel

Research output: Contribution to journalArticle

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Abstract

In areas with longer liver transplantation (LT) wait times, liver resection (LR) offers an appropriate alternative in selected patients with hepatocellular carcinoma (HCC). We identified adults with HCC undergoing LT or LR from the United States Nationwide Inpatient Sample from 1998-2008. United Network for Organ Sharing regions were assigned lower rank indicating shorter wait time for patients with Model for End-Stage Liver Disease (MELD) scores of 19-24 or ≥25. We used multivariate adjusted analysis to assess the odds of LR versus LT comparing patients by region. Of 4,516 patients, 40% received LT and 60% received LR. When ranked by wait times for MELD 19-24, the 3rd, 8th, and 11th ranked regions had decreased odds of LR versus LT (region 3: Odds ratio [OR] 0.3, 95% confidence interval [CI] 0.2-0.6; region 8: OR 0.5, 95% CI 0.3-0.9; region 5: OR 0.3, 95% CI 0.2-0.6), whereas the 10th ranked region had increased odds (region 1: OR 1.9, 95% CI 1.1-3.4) compared with the region with the shortest wait time, region 10. When ranked by wait times for MELD ≥25, all regions except the 10th ranked region (region 5) had increased odds compared with the region with the shortest wait time, region 3 (OR 1.6-5.6; P <.001). Regional variations of LT versus LR are not completely explained by transplant wait times.

Original languageEnglish (US)
Pages (from-to)199-201
Number of pages3
JournalTransplantation Proceedings
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2014

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Hepatocellular Carcinoma
Liver Transplantation
Transplants
Liver
Odds Ratio
End Stage Liver Disease
Confidence Intervals
Inpatients
Multivariate Analysis

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Medicine(all)

Cite this

Are hepatocellular carcinoma patients more likely to receive liver resection in regions with longer transplant wait times? / Anderson, Jamie; Hemming, A. W.; Chang, D. C.; Talamini, M. A.; Mekeel, K. L.

In: Transplantation Proceedings, Vol. 46, No. 1, 01.01.2014, p. 199-201.

Research output: Contribution to journalArticle

Anderson, Jamie ; Hemming, A. W. ; Chang, D. C. ; Talamini, M. A. ; Mekeel, K. L. / Are hepatocellular carcinoma patients more likely to receive liver resection in regions with longer transplant wait times?. In: Transplantation Proceedings. 2014 ; Vol. 46, No. 1. pp. 199-201.
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