Are cutaneous hypersensitivity tests to inhalant allergens a severity marker for vernal keratoconjunctivitis?

Lauro Augusto de Oliveira, Marcia Carvalho Mallozi, Dirceu Sole, Denise de Freitas, Luciene Barbosa de Sousa, Mark J Mannis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: The purpose of this study was to analyze the cutaneous sensitivity to a variety of allergens in patients with vernal keratoconjunctivitis (VKC) and to demonstrate the relation between skin response and clinical aspects of the disease. Methods: Twenty patients with vernal kerato-conjunctivitis were randomly chosen from the External Disease and Cornea Sector. They were clinically evaluated and a score ranging from 0 to 20 was applied based on signs,and symptoms on ophthalmic examination. All subjects underwent a skin prick test agains standardized allergens, such as house dust mites D. pteronyssinus, D. farinae, and Blomia tropicalis, as well as allergens from cat, dog, fungi and feather, Results: Seventy-five per'cent of patients, were positive for at least one of the allergens tested. House dust mites were responsible for the majority of the cases (75%), There was a poor correlation between the clinical score and sensitivity to allergens (r= 0.119 for fungi; r= - 0.174 for dog; r= - 0.243 for house dust mites; r= - 0.090 for feather). A significant correlation was found only for cat allergen extract(r= - 0.510; p=0.024) Concluslon: Our study demonstrated poor correlation between cutaneous hypersensitivity tests and clinic finding in patients with vernal keratoconjuntivitis. We concluded, that skin response to inhalant allergens is not a useful test, to identify clinical severity and chronicity of inflammatory process in this disease.

Original languageEnglish (US)
Pages (from-to)991-995
Number of pages5
JournalArquivos Brasileiros de Oftalmologia
Issue number6
StatePublished - Nov 2007


  • Conjunctiva/immunology
  • Conjunctivitis, allergic
  • Hypersensitivity
  • Skin tests

ASJC Scopus subject areas

  • Ophthalmology


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