Architecture and Cellular Composition of the Air-Blood Tissue Barrier

Kent E Pinkerton; Peter Gehr; Alejandro Castañeda; James D. Crapo

doi:10.1016/B978-0-12-404577-4.00009-6

Architecture and Cellular Composition of the Air-Blood Tissue Barrier

Kent E Pinkerton, Peter Gehr, Alejandro Castañeda, James D. Crapo

Research output: Chapter in Book/Report/Conference proceeding › Chapter

14 Scopus citations

Abstract

There are over 4000 different varieties of mammals. Among the terrestrial mammals, body size ranges from the 2-g Etruscan shrew to the 6600-kg African elephant. Lung tissue mass involved in gas exchange in this class of animals also covers a wide spectrum. Differences in the dimensions of the mammalian respiratory system are intriguing, since those pulmonary tissues involved in gas exchange are strikingly similar in organization and cellular composition, yet serve vastly different oxygen consumption needs in a highly efficient manner for animals spanning more than a 3-million-fold difference in total body mass. The purpose of this chapter is to review and to compare the anatomy and cellular composition of the alveolar region in mammalian lungs.

Original language	English (US)
Title of host publication	Comparative Biology of the Normal Lung: Second Edition
Publisher	Elsevier Inc.
Pages	105-117
Number of pages	13
ISBN (Print)	9780124045774, 9780124047266
DOIs	https://doi.org/10.1016/B978-0-12-404577-4.00009-6
State	Published - Mar 18 2015
Externally published	Yes

Keywords

Air-blood tissue barrier
Allometric plot
Alveolar epithelium
Capillary
Comparative lung anatomy
Dendritic cells
Endothelium
Gas exchange
Lung interstitium
Lung parenchyma

ASJC Scopus subject areas

Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/B978-0-12-404577-4.00009-6

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Cite this

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