Arachnoid granulations of the temporal bone: A histologic study of dural and osseous penetration

Margaret Yew, Basil Dubbs, Olivia Tong, George T. Nager, John K. Niparko, Arzu Tatlipinar, Howard W. Francis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Hypothesis: Arachnoid granulations (AG) are more prevalent along the middle fossa surface of the temporal bone, where they produce larger bony defects than those occurring on the posterior surface. Background: Dural and bony defects formed by AGs are proposed to lead to spontaneous meningoencephaloceles and cerebrospinal fluid otorrhea. They most commonly occur at the tegmen and in individuals older than 40 years. Methods: Vertically sectioned temporal bones were evaluated using light microscopy to determine AG histology, distribution, and morphometry and to determine the prevalence of AG penetration in the donor population. Results: AGs were observed to penetrate the dura mater and make direct contact with cortical surfaces in 12.7% of donors in the Johns Hopkins Temporal Bone Collection. AGs occurred at middle fossa sites 13% more frequently than at posterior fossa sites. At middle fossa sites AGs produced significantly larger bony openings and were more likely to be associated with herniating brain tissue. Donors with AGs were significantly older, and all were in the late 30s or older. Conclusion: Erosion of the temporal bone by AGs is not a rare occurrence in the population and becomes increasingly prevalent with age. It is estimated that 14 in 1,000 donors were at greatest risk of eventual cerebrospinal fluid leakage at the tegmen. The age and anatomic distribution described in this study strengthens the notion that AG penetration plays a role in the pathophysiology of spontaneous cerebrospinal fluid leaks and meningoencephaloceles of the temporal bone.

Original languageEnglish (US)
Pages (from-to)602-609
Number of pages8
JournalOtology and Neurotology
Volume32
Issue number4
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Fingerprint

Arachnoid
Temporal Bone
Cerebrospinal Fluid Otorrhea
Dura Mater
Age Distribution
Population
Microscopy
Histology
Light
Brain

Keywords

  • Arachnoid granulation
  • Cerebrospinal fluid leak
  • Histology
  • Meningoencephalocele
  • Otorrhea
  • Temporal bone

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

Cite this

Arachnoid granulations of the temporal bone : A histologic study of dural and osseous penetration. / Yew, Margaret; Dubbs, Basil; Tong, Olivia; Nager, George T.; Niparko, John K.; Tatlipinar, Arzu; Francis, Howard W.

In: Otology and Neurotology, Vol. 32, No. 4, 01.06.2011, p. 602-609.

Research output: Contribution to journalArticle

Yew, Margaret ; Dubbs, Basil ; Tong, Olivia ; Nager, George T. ; Niparko, John K. ; Tatlipinar, Arzu ; Francis, Howard W. / Arachnoid granulations of the temporal bone : A histologic study of dural and osseous penetration. In: Otology and Neurotology. 2011 ; Vol. 32, No. 4. pp. 602-609.
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