Arachidonic acid immunoregulation in lambs persistently infected with border disease virus

M. M. Sawyer, L. L. Williams, A. C. Odeón, S. N. Giri, Bennie Osburn

Research output: Contribution to journalArticle

Abstract

To evaluate arachidonic acid-related immunoregulatory mechanisms during long-term persistent pestivirus infection, we measured plasma contents of leukotriene C4 (LTC4), prostaglandin D2 (PGD2) and their plasma fatty acid (FA) precursor, arachidonic acid (AA), in six lambs with congenital border disease (BD). Significantly elevated average plasma LTC4 during the first half year of life was associated with increased PDG2 when compared to uninfected control lambs. Significantly elevated total plasma esterified AA stores suggest an effective BDV-mediated prostenoid immunostimulation. However, at 1 yr old, prostenoid secretion had fallen to normal (LTC4) or below normal (PGD2) levels. In contrast, there remained significantly elevated plasma esterified AA, present as available substrate for formation of these anti-viral immunoregulatory agents. These results suggested that preventing mobilization of AA from lipid stores for effective immune responses may be a viral strategy of BD virus that is associated with long term border disease effects.

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume16
Issue number4
DOIs
StatePublished - Jan 1 1993

Keywords

  • Arachidonic acid
  • congenital infection
  • congenital rubella
  • leukotriene
  • pestivirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • veterinary(all)
  • Infectious Diseases

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