Arabinogalactan-coated superparamagnetic iron oxide: Effect of particle size in liver MRI

Erik R Wisner, E. G. Amparo, D. R. Vera, J. M. Brock, T. W. Barlow, Stephen M Griffey, C. Drake, Richard W Katzberg

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Objective: We evaluated the effect of particle size on MR contrast- enhancing properties of arabinogalactan-coated superparamagnetic iron oxide (AG-SPIO) in tumor-bearing rats. Materials and Methods: T2*-weighted gradient-recalled echo MR studies were performed on rats with surgically implanted liver tumors before and after AG-SPIO administration. Contrast-to- noise ratio (CNR) and percent contrast enhancement (PCE) were calculated for animals given small (15.7 ± 9.5 nm; n = 6), medium (49.1 ± 19.7 nm; n = 4), and large (86.9 ± 27.5 nm; n =4) particles intravenously (10 μmol Fe/kg). Results: Postcontrast CNRs were 15.8 ± 6.9, 8.9 ± 4.1, and 10.0 ± 1.8 for small, medium, and large particle groups, respectively. The PCE was -60.0 ± 3.3, -75.5 ± 7.9, and -80.5 ± 1.2%. There was a significant difference in pre-versus postcontrast CNR for all particle sizes (p < 0.001) and in PCE for small particles as compared with the two larger sizes (p < 0.001). There was no between-group statistical difference in postcontrast CNR for any particle size. Conclusion: Larger AG-SPIO particles slightly improve liver contrast enhancement, but have no significant effect on hepatic lesion detection as assessed by CNR.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalJournal of Computer Assisted Tomography
Issue number2
StatePublished - 1995


  • Contrast media
  • Iron oxide
  • Liver
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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