Arabinogalactan-coated superparamagnetic iron oxide: Effect of particle size in liver MRI

Erik R Wisner, E. G. Amparo, D. R. Vera, J. M. Brock, T. W. Barlow, Stephen M Griffey, C. Drake, Richard W Katzberg

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: We evaluated the effect of particle size on MR contrast- enhancing properties of arabinogalactan-coated superparamagnetic iron oxide (AG-SPIO) in tumor-bearing rats. Materials and Methods: T2*-weighted gradient-recalled echo MR studies were performed on rats with surgically implanted liver tumors before and after AG-SPIO administration. Contrast-to- noise ratio (CNR) and percent contrast enhancement (PCE) were calculated for animals given small (15.7 ± 9.5 nm; n = 6), medium (49.1 ± 19.7 nm; n = 4), and large (86.9 ± 27.5 nm; n =4) particles intravenously (10 μmol Fe/kg). Results: Postcontrast CNRs were 15.8 ± 6.9, 8.9 ± 4.1, and 10.0 ± 1.8 for small, medium, and large particle groups, respectively. The PCE was -60.0 ± 3.3, -75.5 ± 7.9, and -80.5 ± 1.2%. There was a significant difference in pre-versus postcontrast CNR for all particle sizes (p < 0.001) and in PCE for small particles as compared with the two larger sizes (p < 0.001). There was no between-group statistical difference in postcontrast CNR for any particle size. Conclusion: Larger AG-SPIO particles slightly improve liver contrast enhancement, but have no significant effect on hepatic lesion detection as assessed by CNR.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume19
Issue number2
StatePublished - 1995

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Particle Size
Noise
Liver
Neoplasms
ferric oxide
arabinogalactan

Keywords

  • Contrast media
  • Iron oxide
  • Liver
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Wisner, E. R., Amparo, E. G., Vera, D. R., Brock, J. M., Barlow, T. W., Griffey, S. M., ... Katzberg, R. W. (1995). Arabinogalactan-coated superparamagnetic iron oxide: Effect of particle size in liver MRI. Journal of Computer Assisted Tomography, 19(2), 211-215.

Arabinogalactan-coated superparamagnetic iron oxide : Effect of particle size in liver MRI. / Wisner, Erik R; Amparo, E. G.; Vera, D. R.; Brock, J. M.; Barlow, T. W.; Griffey, Stephen M; Drake, C.; Katzberg, Richard W.

In: Journal of Computer Assisted Tomography, Vol. 19, No. 2, 1995, p. 211-215.

Research output: Contribution to journalArticle

Wisner, ER, Amparo, EG, Vera, DR, Brock, JM, Barlow, TW, Griffey, SM, Drake, C & Katzberg, RW 1995, 'Arabinogalactan-coated superparamagnetic iron oxide: Effect of particle size in liver MRI', Journal of Computer Assisted Tomography, vol. 19, no. 2, pp. 211-215.
Wisner, Erik R ; Amparo, E. G. ; Vera, D. R. ; Brock, J. M. ; Barlow, T. W. ; Griffey, Stephen M ; Drake, C. ; Katzberg, Richard W. / Arabinogalactan-coated superparamagnetic iron oxide : Effect of particle size in liver MRI. In: Journal of Computer Assisted Tomography. 1995 ; Vol. 19, No. 2. pp. 211-215.
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abstract = "Objective: We evaluated the effect of particle size on MR contrast- enhancing properties of arabinogalactan-coated superparamagnetic iron oxide (AG-SPIO) in tumor-bearing rats. Materials and Methods: T2*-weighted gradient-recalled echo MR studies were performed on rats with surgically implanted liver tumors before and after AG-SPIO administration. Contrast-to- noise ratio (CNR) and percent contrast enhancement (PCE) were calculated for animals given small (15.7 ± 9.5 nm; n = 6), medium (49.1 ± 19.7 nm; n = 4), and large (86.9 ± 27.5 nm; n =4) particles intravenously (10 μmol Fe/kg). Results: Postcontrast CNRs were 15.8 ± 6.9, 8.9 ± 4.1, and 10.0 ± 1.8 for small, medium, and large particle groups, respectively. The PCE was -60.0 ± 3.3, -75.5 ± 7.9, and -80.5 ± 1.2{\%}. There was a significant difference in pre-versus postcontrast CNR for all particle sizes (p < 0.001) and in PCE for small particles as compared with the two larger sizes (p < 0.001). There was no between-group statistical difference in postcontrast CNR for any particle size. Conclusion: Larger AG-SPIO particles slightly improve liver contrast enhancement, but have no significant effect on hepatic lesion detection as assessed by CNR.",
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AU - Amparo, E. G.

AU - Vera, D. R.

AU - Brock, J. M.

AU - Barlow, T. W.

AU - Griffey, Stephen M

AU - Drake, C.

AU - Katzberg, Richard W

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N2 - Objective: We evaluated the effect of particle size on MR contrast- enhancing properties of arabinogalactan-coated superparamagnetic iron oxide (AG-SPIO) in tumor-bearing rats. Materials and Methods: T2*-weighted gradient-recalled echo MR studies were performed on rats with surgically implanted liver tumors before and after AG-SPIO administration. Contrast-to- noise ratio (CNR) and percent contrast enhancement (PCE) were calculated for animals given small (15.7 ± 9.5 nm; n = 6), medium (49.1 ± 19.7 nm; n = 4), and large (86.9 ± 27.5 nm; n =4) particles intravenously (10 μmol Fe/kg). Results: Postcontrast CNRs were 15.8 ± 6.9, 8.9 ± 4.1, and 10.0 ± 1.8 for small, medium, and large particle groups, respectively. The PCE was -60.0 ± 3.3, -75.5 ± 7.9, and -80.5 ± 1.2%. There was a significant difference in pre-versus postcontrast CNR for all particle sizes (p < 0.001) and in PCE for small particles as compared with the two larger sizes (p < 0.001). There was no between-group statistical difference in postcontrast CNR for any particle size. Conclusion: Larger AG-SPIO particles slightly improve liver contrast enhancement, but have no significant effect on hepatic lesion detection as assessed by CNR.

AB - Objective: We evaluated the effect of particle size on MR contrast- enhancing properties of arabinogalactan-coated superparamagnetic iron oxide (AG-SPIO) in tumor-bearing rats. Materials and Methods: T2*-weighted gradient-recalled echo MR studies were performed on rats with surgically implanted liver tumors before and after AG-SPIO administration. Contrast-to- noise ratio (CNR) and percent contrast enhancement (PCE) were calculated for animals given small (15.7 ± 9.5 nm; n = 6), medium (49.1 ± 19.7 nm; n = 4), and large (86.9 ± 27.5 nm; n =4) particles intravenously (10 μmol Fe/kg). Results: Postcontrast CNRs were 15.8 ± 6.9, 8.9 ± 4.1, and 10.0 ± 1.8 for small, medium, and large particle groups, respectively. The PCE was -60.0 ± 3.3, -75.5 ± 7.9, and -80.5 ± 1.2%. There was a significant difference in pre-versus postcontrast CNR for all particle sizes (p < 0.001) and in PCE for small particles as compared with the two larger sizes (p < 0.001). There was no between-group statistical difference in postcontrast CNR for any particle size. Conclusion: Larger AG-SPIO particles slightly improve liver contrast enhancement, but have no significant effect on hepatic lesion detection as assessed by CNR.

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