Aqueous or emulsified diazepam in upper endoscopy: A randomized trial

S. C S Chung, Joseph Leung

Research output: Contribution to journalArticlepeer-review


A randomized comparison between diazepam in aqueous form and in fatty emulsion was performed in Chinese patients undergoing upper gastrointestinal endoscopy. One hundred and eighty-four patients completed the study. The sedative effect is similar with both preparations. Aqueous diazepam caused significantly more pain on injection (75%) and more late venous complication (41%) than the emulsified form (13% and 9% respectively). Thrombosis and thrombophlebitis frequently extended beyond the site of injection. Diazepam in emulsion form caused significantly less venous complications and is therefore superior to the aqueous form for intravenous use.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalJournal of gastroenterology and hepatology
Issue number2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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