Aquatic polymers can drive pathogen transmission in coastal ecosystems

Karen Shapiro, Colin Krusor, Fernanda F.M. Mazzillo, Patricia A Conrad, John L. Largier, Jonna A Mazet, Mary W. Silver

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Gelatinous polymers including extracellular polymeric substances (EPSs) are fundamental to biophysical processes in aquatic habitats, including mediating aggregation processes and functioning as the matrix of biofilms. Yet insight into the impact of these sticky molecules on the environmental transmission of pathogens in the ocean is limited. We used the zoonotic parasite Toxoplasma gondii as a model to evaluate polymer-mediated mechanisms that promote transmission of terrestrially derived pathogens to marine fauna and humans. We show that transparent exopolymer particles, a particulate form of EPS, enhance T. gondii association with marine aggregates, material consumed by organisms otherwise unable to access micrometre-sized particles. Adhesion to EPS biofilms on macroalgae also captures T. gondii from the water, enabling uptake of pathogens by invertebrates that feed on kelp surfaces. We demonstrate the acquisition, concentration and retention of T. gondii by kelp-grazing snails, which can transmit T. gondii to threatened California sea otters. Results highlight novel mechanisms whereby aquatic polymers facilitate incorporation of pathogens into food webs via association with particle aggregates and biofilms. Identifying the critical role of invisible polymers in transmission of pathogens in the ocean represents a fundamental advance in understanding and mitigating the health impacts of coastal habitat pollution with contaminated runoff.

Original languageEnglish (US)
JournalProceedings. Biological sciences / The Royal Society
Volume281
Issue number1795
DOIs
StatePublished - Nov 22 2014

Fingerprint

Infectious Disease Transmission
Toxoplasma
Pathogens
Toxoplasma gondii
Ecosystems
Ecosystem
polymers
Polymers
pathogen
polymer
Biofilms
Kelp
ecosystems
pathogens
biofilm
macroalgae
Oceans and Seas
Biophysical Phenomena
Otters
oceans

Keywords

  • extracellular polymeric substances
  • marine transmission
  • sea otter
  • Toxoplasma gondii
  • transparent exopolymer particles
  • zoonotic pathogen

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Aquatic polymers can drive pathogen transmission in coastal ecosystems. / Shapiro, Karen; Krusor, Colin; Mazzillo, Fernanda F.M.; Conrad, Patricia A; Largier, John L.; Mazet, Jonna A; Silver, Mary W.

In: Proceedings. Biological sciences / The Royal Society, Vol. 281, No. 1795, 22.11.2014.

Research output: Contribution to journalArticle

Shapiro, Karen ; Krusor, Colin ; Mazzillo, Fernanda F.M. ; Conrad, Patricia A ; Largier, John L. ; Mazet, Jonna A ; Silver, Mary W. / Aquatic polymers can drive pathogen transmission in coastal ecosystems. In: Proceedings. Biological sciences / The Royal Society. 2014 ; Vol. 281, No. 1795.
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