Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma

Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Satoshi Kurabe, Kouichirou Okamoto, Hiroshi Aoki, Hiroki Kitaura, Akiyoshi Kakita, Yukihiko Fujii, Vincent J. Huber, Hironaka Igarashi, Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


BACKGROUND: Aquaporin (AQP) water channels play a signifcant role in mesenchymalmicrovascular proliferation and infltrative growth. AQPs are highly expressed in malignantastrocytomas, and a positive correlation is observed between their expression levels andhistological tumor grade.OBJECTIVE: To examine the utility of aquaporin positron emission tomography (PET) fordifferentiating between astrocytoma grade III and grade IV using the AQP radioligand[11C]TGN-020.METHODS: Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues ofastrocytoma patients were examined for histopathological grading using the WHO classifcation standard and expression of AQP1 and AQP4 immunohistochemically.RESULTS: Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P <.001) forboth tumor grades. Importantly, mean standardized uptake values of astrocytoma gradeIV were signifcantly higher than grade III (P <.01).CONCLUSION: Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as anoninvasive diagnostic tool would lead to advancements in the management of thesemalignant brain tumors.

Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
Issue number6
StatePublished - Jan 1 2018


  • Aquaporin1 (AQP1)
  • Aquaporin4 (AQP4)
  • Astrocytoma
  • Positron emission tomography (PET)
  • [11C]TGN-020

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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