Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma

Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Satoshi Kurabe, Kouichirou Okamoto, Hiroshi Aoki, Hiroki Kitaura, Akiyoshi Kakita, Yukihiko Fujii, Vincent J. Huber, Hironaka Igarashi, Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Aquaporin (AQP) water channels play a signifcant role in mesenchymalmicrovascular proliferation and infltrative growth. AQPs are highly expressed in malignantastrocytomas, and a positive correlation is observed between their expression levels andhistological tumor grade.OBJECTIVE: To examine the utility of aquaporin positron emission tomography (PET) fordifferentiating between astrocytoma grade III and grade IV using the AQP radioligand[11C]TGN-020.METHODS: Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues ofastrocytoma patients were examined for histopathological grading using the WHO classifcation standard and expression of AQP1 and AQP4 immunohistochemically.RESULTS: Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P <.001) forboth tumor grades. Importantly, mean standardized uptake values of astrocytoma gradeIV were signifcantly higher than grade III (P <.01).CONCLUSION: Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as anoninvasive diagnostic tool would lead to advancements in the management of thesemalignant brain tumors.

Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
JournalNeurosurgery
Volume82
Issue number6
DOIs
StatePublished - Jan 1 2018

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Aquaporins
Astrocytoma
Positron-Emission Tomography
Glioblastoma
Brain Neoplasms
Volunteers
Neoplasms
Growth
2-(nicotinamide)-1,3,4-thiadiazole

Keywords

  • Aquaporin1 (AQP1)
  • Aquaporin4 (AQP4)
  • Astrocytoma
  • Positron emission tomography (PET)
  • [11C]TGN-020

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Suzuki, Y., Nakamura, Y., Yamada, K., Kurabe, S., Okamoto, K., Aoki, H., ... Nakada, T. (2018). Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma. Neurosurgery, 82(6), 842-846. https://doi.org/10.1093/neuros/nyx314

Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma. / Suzuki, Yuji; Nakamura, Yukihiro; Yamada, Kenichi; Kurabe, Satoshi; Okamoto, Kouichirou; Aoki, Hiroshi; Kitaura, Hiroki; Kakita, Akiyoshi; Fujii, Yukihiko; Huber, Vincent J.; Igarashi, Hironaka; Kwee, Ingrid; Nakada, Tsutomu.

In: Neurosurgery, Vol. 82, No. 6, 01.01.2018, p. 842-846.

Research output: Contribution to journalArticle

Suzuki, Y, Nakamura, Y, Yamada, K, Kurabe, S, Okamoto, K, Aoki, H, Kitaura, H, Kakita, A, Fujii, Y, Huber, VJ, Igarashi, H, Kwee, I & Nakada, T 2018, 'Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma', Neurosurgery, vol. 82, no. 6, pp. 842-846. https://doi.org/10.1093/neuros/nyx314
Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H et al. Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma. Neurosurgery. 2018 Jan 1;82(6):842-846. https://doi.org/10.1093/neuros/nyx314
Suzuki, Yuji ; Nakamura, Yukihiro ; Yamada, Kenichi ; Kurabe, Satoshi ; Okamoto, Kouichirou ; Aoki, Hiroshi ; Kitaura, Hiroki ; Kakita, Akiyoshi ; Fujii, Yukihiko ; Huber, Vincent J. ; Igarashi, Hironaka ; Kwee, Ingrid ; Nakada, Tsutomu. / Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma. In: Neurosurgery. 2018 ; Vol. 82, No. 6. pp. 842-846.
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abstract = "BACKGROUND: Aquaporin (AQP) water channels play a signifcant role in mesenchymalmicrovascular proliferation and infltrative growth. AQPs are highly expressed in malignantastrocytomas, and a positive correlation is observed between their expression levels andhistological tumor grade.OBJECTIVE: To examine the utility of aquaporin positron emission tomography (PET) fordifferentiating between astrocytoma grade III and grade IV using the AQP radioligand[11C]TGN-020.METHODS: Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues ofastrocytoma patients were examined for histopathological grading using the WHO classifcation standard and expression of AQP1 and AQP4 immunohistochemically.RESULTS: Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P <.001) forboth tumor grades. Importantly, mean standardized uptake values of astrocytoma gradeIV were signifcantly higher than grade III (P <.01).CONCLUSION: Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as anoninvasive diagnostic tool would lead to advancements in the management of thesemalignant brain tumors.",
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T1 - Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma

AU - Suzuki, Yuji

AU - Nakamura, Yukihiro

AU - Yamada, Kenichi

AU - Kurabe, Satoshi

AU - Okamoto, Kouichirou

AU - Aoki, Hiroshi

AU - Kitaura, Hiroki

AU - Kakita, Akiyoshi

AU - Fujii, Yukihiko

AU - Huber, Vincent J.

AU - Igarashi, Hironaka

AU - Kwee, Ingrid

AU - Nakada, Tsutomu

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: Aquaporin (AQP) water channels play a signifcant role in mesenchymalmicrovascular proliferation and infltrative growth. AQPs are highly expressed in malignantastrocytomas, and a positive correlation is observed between their expression levels andhistological tumor grade.OBJECTIVE: To examine the utility of aquaporin positron emission tomography (PET) fordifferentiating between astrocytoma grade III and grade IV using the AQP radioligand[11C]TGN-020.METHODS: Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues ofastrocytoma patients were examined for histopathological grading using the WHO classifcation standard and expression of AQP1 and AQP4 immunohistochemically.RESULTS: Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P <.001) forboth tumor grades. Importantly, mean standardized uptake values of astrocytoma gradeIV were signifcantly higher than grade III (P <.01).CONCLUSION: Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as anoninvasive diagnostic tool would lead to advancements in the management of thesemalignant brain tumors.

AB - BACKGROUND: Aquaporin (AQP) water channels play a signifcant role in mesenchymalmicrovascular proliferation and infltrative growth. AQPs are highly expressed in malignantastrocytomas, and a positive correlation is observed between their expression levels andhistological tumor grade.OBJECTIVE: To examine the utility of aquaporin positron emission tomography (PET) fordifferentiating between astrocytoma grade III and grade IV using the AQP radioligand[11C]TGN-020.METHODS: Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues ofastrocytoma patients were examined for histopathological grading using the WHO classifcation standard and expression of AQP1 and AQP4 immunohistochemically.RESULTS: Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P <.001) forboth tumor grades. Importantly, mean standardized uptake values of astrocytoma gradeIV were signifcantly higher than grade III (P <.01).CONCLUSION: Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as anoninvasive diagnostic tool would lead to advancements in the management of thesemalignant brain tumors.

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KW - [11C]TGN-020

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