Aquaporin-4 functionality and virchow-robin space water dynamics: Physiological model for neurovascular coupling and glymphatic flow

Tsutomu Nakada, Ingrid Kwee, Hironaka Igarashi, Yuji Suzuki

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries. Instead, fluid dynamics inside the BBB is realized by aquaporin-4 (AQP-4), the water channel that connects astrocyte cytoplasm and extracellular (interstitial) fluid. Brain interstitial fluid dynamics, and therefore AQP-4, are now recognized as essential for two unique functions, namely, neurovascular coupling and glymphatic flow, the brain equivalent of systemic lymphatics.

Original languageEnglish (US)
Article number1798
JournalInternational Journal of Molecular Sciences
Volume18
Issue number8
DOIs
StatePublished - Aug 18 2017

Fingerprint

Physiological models
Aquaporin 4
blood-brain barrier
Songbirds
Blood-Brain Barrier
brain
Extracellular Fluid
Brain
interstitials
Hydrodynamics
Water
endothelium
water
Vascular Endothelium
fluid dynamics
Fluid dynamics
Fluids
fluids
Aquaporins
Hydrostatic Pressure

Keywords

  • Glia limitans externa
  • Hagen-Poiseuille equation
  • Interstitial flow
  • RCBF
  • Starling resister

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Aquaporin-4 functionality and virchow-robin space water dynamics : Physiological model for neurovascular coupling and glymphatic flow. / Nakada, Tsutomu; Kwee, Ingrid; Igarashi, Hironaka; Suzuki, Yuji.

In: International Journal of Molecular Sciences, Vol. 18, No. 8, 1798, 18.08.2017.

Research output: Contribution to journalReview article

@article{bc035bc399024731a9c220a1c8402be1,
title = "Aquaporin-4 functionality and virchow-robin space water dynamics: Physiological model for neurovascular coupling and glymphatic flow",
abstract = "The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries. Instead, fluid dynamics inside the BBB is realized by aquaporin-4 (AQP-4), the water channel that connects astrocyte cytoplasm and extracellular (interstitial) fluid. Brain interstitial fluid dynamics, and therefore AQP-4, are now recognized as essential for two unique functions, namely, neurovascular coupling and glymphatic flow, the brain equivalent of systemic lymphatics.",
keywords = "Glia limitans externa, Hagen-Poiseuille equation, Interstitial flow, RCBF, Starling resister",
author = "Tsutomu Nakada and Ingrid Kwee and Hironaka Igarashi and Yuji Suzuki",
year = "2017",
month = "8",
day = "18",
doi = "10.3390/ijms18081798",
language = "English (US)",
volume = "18",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",

}

TY - JOUR

T1 - Aquaporin-4 functionality and virchow-robin space water dynamics

T2 - Physiological model for neurovascular coupling and glymphatic flow

AU - Nakada, Tsutomu

AU - Kwee, Ingrid

AU - Igarashi, Hironaka

AU - Suzuki, Yuji

PY - 2017/8/18

Y1 - 2017/8/18

N2 - The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries. Instead, fluid dynamics inside the BBB is realized by aquaporin-4 (AQP-4), the water channel that connects astrocyte cytoplasm and extracellular (interstitial) fluid. Brain interstitial fluid dynamics, and therefore AQP-4, are now recognized as essential for two unique functions, namely, neurovascular coupling and glymphatic flow, the brain equivalent of systemic lymphatics.

AB - The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries. Instead, fluid dynamics inside the BBB is realized by aquaporin-4 (AQP-4), the water channel that connects astrocyte cytoplasm and extracellular (interstitial) fluid. Brain interstitial fluid dynamics, and therefore AQP-4, are now recognized as essential for two unique functions, namely, neurovascular coupling and glymphatic flow, the brain equivalent of systemic lymphatics.

KW - Glia limitans externa

KW - Hagen-Poiseuille equation

KW - Interstitial flow

KW - RCBF

KW - Starling resister

UR - http://www.scopus.com/inward/record.url?scp=85028036680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028036680&partnerID=8YFLogxK

U2 - 10.3390/ijms18081798

DO - 10.3390/ijms18081798

M3 - Review article

C2 - 28820467

AN - SCOPUS:85028036680

VL - 18

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 8

M1 - 1798

ER -