Aptasensors for biosecurity applications

Nicholas O Fischer, Theodore M. Tarasow, Jeffrey B H Tok

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Nucleic acid (aptasensors) have found steadily increased utility and application over the past decade. In particular, aptamers have been touted as a valuable complement to and, in some cases, replacement for antibodies owing to their structural and functional robustness as well as their ease in generation and synthesis. They are thus attractive for biosecurity applications (e.g. pathogen detection) and are especially well suited because their in vitro generation process does not require infection of any host systems. Herein we provide a brief overview of the aptamers generated against pathogens and toxins over the past few years. In addition, a few recently described detection platforms using aptamers and potentially suitable applications for biosecurity will be discussed.

Original languageEnglish (US)
Pages (from-to)316-328
Number of pages13
JournalCurrent Opinion in Chemical Biology
Volume11
Issue number3
DOIs
StatePublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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