Aprotinin improves outcome of single-ventricle palliation

James S. Tweddell, Stuart Berger, Peter C. Frommelt, Andrew N Pelech, David A. Lewis, Raymond T. Fedderly, Michele A. Frommelt, Terrence S. McManus, Kathleen A. Mussatto, Maryanne W. Kessel, S. Bert Litwin

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31 Scopus citations


Background. Elevation of pulmonary vascular resistance as a consequence of cardiopulmonary bypass may lead to failure of single-ventricle palliation. We reviewed our experience with aprotinin, a nonspecific serine protease inhibitor, to determine whether it could ameliorate the inflammatory effects of cardiopulmonary bypass and improve outcome of single-ventricle palliation. Methds. Forty-six consecutive patients undergoing single-ventricle palliation using cardiopulmonary bypass were reviewed retrospectively. Aprotinin was used in 8 of 30 bidirectional cavopulmonary shunt and 10 of 16 Fontan procedures. Results. Aprotinin use was associated with a decrease in the early postoperative transpulmonary gradient among patients undergoing Fontan and bidirectional cavopulmonary shunt procedures. The bidirectional cavopulmonary shunt aprotinin group had a higher oxygen saturation and a decrease in quantity and duration of thoracic drainage. Among patients receiving aprotinin there were no episodes of mediastinitis, thrombus formation, or renal failure. Conclusions. Aprotinin use in single-ventricle palliation was associated with decreased transpulmonary gradient and increased oxygen saturation consistent with decreased pulmonary vascular resistance. This retrospective study suggests that aprotinin has a favorable impact on the early postoperative course of single-ventricle palliation.

Original languageEnglish (US)
Pages (from-to)1329-1336
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number5
StatePublished - Nov 1996
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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    Tweddell, J. S., Berger, S., Frommelt, P. C., Pelech, A. N., Lewis, D. A., Fedderly, R. T., Frommelt, M. A., McManus, T. S., Mussatto, K. A., Kessel, M. W., & Litwin, S. B. (1996). Aprotinin improves outcome of single-ventricle palliation. Annals of Thoracic Surgery, 62(5), 1329-1336. https://doi.org/10.1016/0003-4975(96)00670-4