Approach to myopathies

Bjorn E Oskarsson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter provides guidance in how to approach a patient with a suspected myopathy and should in most cases lead to a diagnosis or at least a diagnostic class of myopathy. This textbook has chapters covering all but the rarest types of myopathies and can provide further direction on the workup of specific myopathies. Each of the diagnostic steps-namely, the clinical evaluation, EMG, biopsy, and histological interpretation-involves many features which can be suggestive of certain myopathies, without being definitively diagnostic. To capture and synthesize all the information from each diagnostic step, the workup is ideally performed by the same neuromuscular physician who can perform all three steps. At many institutions this is not possible, and when a team of physicians is used for the workup, then close communication between the neurologist, electromyographer, surgeon, and pathologist is critical. Problems will arise if the referring and performing physicians do not know what questions can be answered by the EMG or how EMG results might shift the odds of diseases in the differential. Likewise the muscle biopsy needs to be performed with knowledge of what muscles were studied by EMG and which muscles will provide the most histological information. The muscle tissue samples need to be big enough and handled appropriately to allow for any preconceived testing. Lastly, the clinical information is critical for the correct interpretation of the muscle histology. When integrated with all the relevant clinical information, the evaluation of muscle histology is more likely to yield a correct diagnosis.

Original languageEnglish (US)
Title of host publicationNeuromuscular Disorders in Clinical Practice
PublisherSpringer New York
Pages1197-1206
Number of pages10
Volume9781461465676
ISBN (Electronic)9781461465676
ISBN (Print)1461465664, 9781461465669
DOIs
StatePublished - Nov 1 2014

Fingerprint

Muscular Diseases
Muscles
Physicians
Histology
Biopsy
Textbooks
Communication

Keywords

  • creatine kinase
  • EMG
  • muscle histology
  • muscle weakness
  • myalgia
  • Myopathy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Oskarsson, B. E. (2014). Approach to myopathies. In Neuromuscular Disorders in Clinical Practice (Vol. 9781461465676, pp. 1197-1206). Springer New York. https://doi.org/10.1007/978-1-4614-6567-6_55

Approach to myopathies. / Oskarsson, Bjorn E.

Neuromuscular Disorders in Clinical Practice. Vol. 9781461465676 Springer New York, 2014. p. 1197-1206.

Research output: Chapter in Book/Report/Conference proceedingChapter

Oskarsson, BE 2014, Approach to myopathies. in Neuromuscular Disorders in Clinical Practice. vol. 9781461465676, Springer New York, pp. 1197-1206. https://doi.org/10.1007/978-1-4614-6567-6_55
Oskarsson BE. Approach to myopathies. In Neuromuscular Disorders in Clinical Practice. Vol. 9781461465676. Springer New York. 2014. p. 1197-1206 https://doi.org/10.1007/978-1-4614-6567-6_55
Oskarsson, Bjorn E. / Approach to myopathies. Neuromuscular Disorders in Clinical Practice. Vol. 9781461465676 Springer New York, 2014. pp. 1197-1206
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