Appraisal of the extent of chronic allograft vasculopathy in animal models: Proposition of a standardized micromorphometric method

Géraldine Rousvoal, Marc A. Rousseau, Mona G. Flores, Dominic C. Borie

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Arterial obstruction due to intimal myproliferation is an outcome used for investigating chronic allograft vasculopathy in animal models. Since harvested tissue may be distorted while processing, discrepancy may happen in the measure of the obstruction. We propose a standardized micromorphometric method for calculating the percentage of obstruction with eliminating the variability in the shape of the vessel cross-section. The mathematical adjustment avoids the overestimation of the percentage of obstruction and improves accuracy.

Original languageEnglish (US)
Pages (from-to)407-409
Number of pages3
JournalAtherosclerosis
Volume181
Issue number2
DOIs
StatePublished - Aug 2005
Externally publishedYes

Keywords

  • Chronic allograft vasculopathy
  • Standardized obstruction percentage: Rat aorta

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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