Applying the ARRIVE Guidelines to an In Vivo Database

Natasha A. Karp, Terry F. Meehan, Hugh Morgan, Jeremy C. Mason, Andrew Blake, Natalja Kurbatova, Damian Smedley, Julius Jacobsen, Richard F. Mott, Vivek Iyer, Peter Matthews, David G. Melvin, Sara Wells, Ann M. Flenniken, Hiroshi Masuya, Shigeharu Wakana, Jacqueline K. White, Kevin C K Lloyd, Corey L. Reynolds, Richard Paylor & 10 others David B. West, Karen L. Svenson, Elissa J. Chesler, Martin Hrabě de Angelis, Glauco P. Tocchini-Valentini, Tania Sorg, Yann Herault, Helen Parkinson, Ann Marie Mallon, Steve D M Brown

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future.

Original languageEnglish (US)
Article numbere1002151
JournalPLoS Biology
Volume13
Issue number5
DOIs
StatePublished - May 20 2015

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animal research
Animals
Databases
Guidelines
phenotype
mice
reproducibility
Manuscripts
Experiments
Research
Knockout Mice
peers
Communication
Transparency
animal communication
Phenotype
animals

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Karp, N. A., Meehan, T. F., Morgan, H., Mason, J. C., Blake, A., Kurbatova, N., ... Brown, S. D. M. (2015). Applying the ARRIVE Guidelines to an In Vivo Database. PLoS Biology, 13(5), [e1002151]. https://doi.org/10.1371/journal.pbio.1002151

Applying the ARRIVE Guidelines to an In Vivo Database. / Karp, Natasha A.; Meehan, Terry F.; Morgan, Hugh; Mason, Jeremy C.; Blake, Andrew; Kurbatova, Natalja; Smedley, Damian; Jacobsen, Julius; Mott, Richard F.; Iyer, Vivek; Matthews, Peter; Melvin, David G.; Wells, Sara; Flenniken, Ann M.; Masuya, Hiroshi; Wakana, Shigeharu; White, Jacqueline K.; Lloyd, Kevin C K; Reynolds, Corey L.; Paylor, Richard; West, David B.; Svenson, Karen L.; Chesler, Elissa J.; de Angelis, Martin Hrabě; Tocchini-Valentini, Glauco P.; Sorg, Tania; Herault, Yann; Parkinson, Helen; Mallon, Ann Marie; Brown, Steve D M.

In: PLoS Biology, Vol. 13, No. 5, e1002151, 20.05.2015.

Research output: Contribution to journalArticle

Karp, NA, Meehan, TF, Morgan, H, Mason, JC, Blake, A, Kurbatova, N, Smedley, D, Jacobsen, J, Mott, RF, Iyer, V, Matthews, P, Melvin, DG, Wells, S, Flenniken, AM, Masuya, H, Wakana, S, White, JK, Lloyd, KCK, Reynolds, CL, Paylor, R, West, DB, Svenson, KL, Chesler, EJ, de Angelis, MH, Tocchini-Valentini, GP, Sorg, T, Herault, Y, Parkinson, H, Mallon, AM & Brown, SDM 2015, 'Applying the ARRIVE Guidelines to an In Vivo Database', PLoS Biology, vol. 13, no. 5, e1002151. https://doi.org/10.1371/journal.pbio.1002151
Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N et al. Applying the ARRIVE Guidelines to an In Vivo Database. PLoS Biology. 2015 May 20;13(5). e1002151. https://doi.org/10.1371/journal.pbio.1002151
Karp, Natasha A. ; Meehan, Terry F. ; Morgan, Hugh ; Mason, Jeremy C. ; Blake, Andrew ; Kurbatova, Natalja ; Smedley, Damian ; Jacobsen, Julius ; Mott, Richard F. ; Iyer, Vivek ; Matthews, Peter ; Melvin, David G. ; Wells, Sara ; Flenniken, Ann M. ; Masuya, Hiroshi ; Wakana, Shigeharu ; White, Jacqueline K. ; Lloyd, Kevin C K ; Reynolds, Corey L. ; Paylor, Richard ; West, David B. ; Svenson, Karen L. ; Chesler, Elissa J. ; de Angelis, Martin Hrabě ; Tocchini-Valentini, Glauco P. ; Sorg, Tania ; Herault, Yann ; Parkinson, Helen ; Mallon, Ann Marie ; Brown, Steve D M. / Applying the ARRIVE Guidelines to an In Vivo Database. In: PLoS Biology. 2015 ; Vol. 13, No. 5.
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