Applications of Molecular Imprinting to the Recognition and Detection of Bioactive Molecules

Scott J. McNiven, Soo Hwan Cheong, Raphael Levi, Yohei Yokobayashi, Takeshi Nakagiri, Kazuyoshi Yano, Isao Karube

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Research in our laboratory has been focused on the development of molecularly imprinted polymers (MIPs) which exhibit selectivites for various biologically active molecules. In an effort to create steroid-selective sensors we have thoroughly investigated the effect of various polymerization conditions on the selectivity of MIPs for testosterone. Separation factors (a) ranging from 3 to 10 were observed for a suite of similar steroids. Furthermore, we report a novel post-polymerization technique by which the selectivity of this type of MIP may be further enhanced. Diastereoselective recognition of peptide derivatives has also been achieved using a novel polymerizable valine derivative as a functional monomer We have also developed an FIA-based sensor for the antibiotic chloramphenicol which relies upon the displacement of a chloramphenicoldye conjugate from an MIP by the drug. The sensor is effective over a wide range of concentrations encompassing the therapeutic dosage.

Original languageEnglish (US)
Pages (from-to)90-108
Number of pages19
JournalACS Symposium Series
Volume703
StatePublished - 1998
Externally publishedYes

Fingerprint

Polymers
Molecules
Sensors
Steroids
Polymerization
Derivatives
Valine
Antibiotics
Chloramphenicol
Peptides
Testosterone
Monomers
Anti-Bacterial Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

McNiven, S. J., Cheong, S. H., Levi, R., Yokobayashi, Y., Nakagiri, T., Yano, K., & Karube, I. (1998). Applications of Molecular Imprinting to the Recognition and Detection of Bioactive Molecules. ACS Symposium Series, 703, 90-108.

Applications of Molecular Imprinting to the Recognition and Detection of Bioactive Molecules. / McNiven, Scott J.; Cheong, Soo Hwan; Levi, Raphael; Yokobayashi, Yohei; Nakagiri, Takeshi; Yano, Kazuyoshi; Karube, Isao.

In: ACS Symposium Series, Vol. 703, 1998, p. 90-108.

Research output: Contribution to journalArticle

McNiven, SJ, Cheong, SH, Levi, R, Yokobayashi, Y, Nakagiri, T, Yano, K & Karube, I 1998, 'Applications of Molecular Imprinting to the Recognition and Detection of Bioactive Molecules', ACS Symposium Series, vol. 703, pp. 90-108.
McNiven SJ, Cheong SH, Levi R, Yokobayashi Y, Nakagiri T, Yano K et al. Applications of Molecular Imprinting to the Recognition and Detection of Bioactive Molecules. ACS Symposium Series. 1998;703:90-108.
McNiven, Scott J. ; Cheong, Soo Hwan ; Levi, Raphael ; Yokobayashi, Yohei ; Nakagiri, Takeshi ; Yano, Kazuyoshi ; Karube, Isao. / Applications of Molecular Imprinting to the Recognition and Detection of Bioactive Molecules. In: ACS Symposium Series. 1998 ; Vol. 703. pp. 90-108.
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