Research in our laboratory has been focused on the development of molecularly imprinted polymers (MIPs) which exhibit selectivites for various biologically active molecules. In an effort to create steroid-selective sensors we have thoroughly investigated the effect of various polymerization conditions on the selectivity of MIPs for testosterone. Separation factors (a) ranging from 3 to 10 were observed for a suite of similar steroids. Furthermore, we report a novel post-polymerization technique by which the selectivity of this type of MIP may be further enhanced. Diastereoselective recognition of peptide derivatives has also been achieved using a novel polymerizable valine derivative as a functional monomer We have also developed an FIA-based sensor for the antibiotic chloramphenicol which relies upon the displacement of a chloramphenicoldye conjugate from an MIP by the drug. The sensor is effective over a wide range of concentrations encompassing the therapeutic dosage.
|Original language||English (US)|
|Number of pages||19|
|Journal||ACS Symposium Series|
|State||Published - 1998|
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