Applications of metabolomics for kidney disease research: From biomarkers to therapeutic targets

Hiromi I. Wettersten, Robert H Weiss

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Metabolomics is one of the relative newcomers of the omics techniques and is likely the one most closely related to actual real-time disease pathophysiology. Hence, it has the power to yield not only specific biomarkers but also insight into the pathophysiology of disease. Despite this power, metabolomics as applied to kidney disease is still in its early adolescence and has not yet reached the mature stage of clinical application, i.e., specific biomarker and therapeutic target discovery. On the other hand, the insight gained from hints into what makes these diseases tick, as is evident from the metabolomics pathways which have been found to be altered in kidney cancer, are now beginning to bear fruit in leading to potential therapeutic targets. It is quite likely that, with greater numbers of clinical materials and with more investigators jumping into the field, metabolomics may well change the course of kidney disease research.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
Issue number1
StatePublished - Jan 2013


  • Biomarker
  • Kidney disease
  • Metabolomics
  • Therapeutic target

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Transplantation
  • Biomedical Engineering


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