Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia

Hyung Jin Park, Ja Won Kim, Kun Ho Song, Kyoung Won Seo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly withimproved clinical signs while the third dogwith recurrent IMT was euthanized due to its deteriorating condition. This case report describesthe efficacy of VLP therapy in refractory IMT patients.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalJournal of Veterinary Science
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Refractory immune-mediated thrombocytopenia
  • Vincristine-loaded platelets

ASJC Scopus subject areas

  • veterinary(all)

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