Application of the Scarff-Bloom-Richardson tumor grading system to fine- needle aspirates of the breast

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Abstract

Assigning a tumor grade to breast cancers provides important prognostic information. This study evaluated the applicability of the Scarff-Bloom- Richardson (SBR) breast cancer grading system to aspiration biopsy cytology. Thirty-five consecutive breast cancer fine-needle aspirates and their surgical specimens were reviewed by two pathologists. An SBR grade of 1-3 was assigned by each pathologist to both the fine-needle aspirate and biopsy specimen, based on the sum of scores given to each of three features: tubular differentiation, nuclear pleomorphism, and mitotic index. Both pathologists assigned the same SBR score to 74.3% of biopsy specimens and 65.7% of fine- needle aspirates. The cytologic grade could be used to predict the histologic grade in as many as 57.1% of cases. The wide disparities in the cytologic and histologic grades in some cases were chiefly due to difficulties in detecting mitoses or tubules in the cytology.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume101
Issue number3
StatePublished - 1994

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Neoplasm Grading
Needles
Breast
Breast Neoplasms
Cell Biology
Mitotic Index
Needle Biopsy
Fine Needle Biopsy
Mitosis
Biopsy
Pathologists
Neoplasms

Keywords

  • Breast cancer
  • Cytology
  • Ductal carcinoma
  • Fine-needle aspiration
  • Prognostic markers
  • Tumor grading

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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title = "Application of the Scarff-Bloom-Richardson tumor grading system to fine- needle aspirates of the breast",
abstract = "Assigning a tumor grade to breast cancers provides important prognostic information. This study evaluated the applicability of the Scarff-Bloom- Richardson (SBR) breast cancer grading system to aspiration biopsy cytology. Thirty-five consecutive breast cancer fine-needle aspirates and their surgical specimens were reviewed by two pathologists. An SBR grade of 1-3 was assigned by each pathologist to both the fine-needle aspirate and biopsy specimen, based on the sum of scores given to each of three features: tubular differentiation, nuclear pleomorphism, and mitotic index. Both pathologists assigned the same SBR score to 74.3{\%} of biopsy specimens and 65.7{\%} of fine- needle aspirates. The cytologic grade could be used to predict the histologic grade in as many as 57.1{\%} of cases. The wide disparities in the cytologic and histologic grades in some cases were chiefly due to difficulties in detecting mitoses or tubules in the cytology.",
keywords = "Breast cancer, Cytology, Ductal carcinoma, Fine-needle aspiration, Prognostic markers, Tumor grading",
author = "Howell, {Lydia P} and Gandour-Edwards, {Regina F} and D. O'Sullivan",
year = "1994",
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AU - Howell, Lydia P

AU - Gandour-Edwards, Regina F

AU - O'Sullivan, D.

PY - 1994

Y1 - 1994

N2 - Assigning a tumor grade to breast cancers provides important prognostic information. This study evaluated the applicability of the Scarff-Bloom- Richardson (SBR) breast cancer grading system to aspiration biopsy cytology. Thirty-five consecutive breast cancer fine-needle aspirates and their surgical specimens were reviewed by two pathologists. An SBR grade of 1-3 was assigned by each pathologist to both the fine-needle aspirate and biopsy specimen, based on the sum of scores given to each of three features: tubular differentiation, nuclear pleomorphism, and mitotic index. Both pathologists assigned the same SBR score to 74.3% of biopsy specimens and 65.7% of fine- needle aspirates. The cytologic grade could be used to predict the histologic grade in as many as 57.1% of cases. The wide disparities in the cytologic and histologic grades in some cases were chiefly due to difficulties in detecting mitoses or tubules in the cytology.

AB - Assigning a tumor grade to breast cancers provides important prognostic information. This study evaluated the applicability of the Scarff-Bloom- Richardson (SBR) breast cancer grading system to aspiration biopsy cytology. Thirty-five consecutive breast cancer fine-needle aspirates and their surgical specimens were reviewed by two pathologists. An SBR grade of 1-3 was assigned by each pathologist to both the fine-needle aspirate and biopsy specimen, based on the sum of scores given to each of three features: tubular differentiation, nuclear pleomorphism, and mitotic index. Both pathologists assigned the same SBR score to 74.3% of biopsy specimens and 65.7% of fine- needle aspirates. The cytologic grade could be used to predict the histologic grade in as many as 57.1% of cases. The wide disparities in the cytologic and histologic grades in some cases were chiefly due to difficulties in detecting mitoses or tubules in the cytology.

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