Abstract
A synthetic chemical library comprised of alkylated and acylated amino acids was synthesized and screened to determine structures that bind to a model target, streptavidin. The library was prepared using 'split synthesis' and screened in a solid phase binding assay. The structure of positively reacting compounds was determined using mass spectroscopy. Positive compounds, together with various structural analogs were synthesized and their binding confirmed. Structures containing both an imidazole moiety and a substituted aromatic residue demonstrated binding.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 146-156 |
| Number of pages | 11 |
| Journal | Drug Development Research |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
Keywords
- Split synthesis
- Streptavidin
- Synthetic chemical library
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Pharmacology
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Stankova, M., Issakova, O., Sepetov, N. F., Krchnak, V., Lam, K., & Lebl, M. (1994). Application of one-read one-structure approach to identification of nonpeptidic ligands. Drug Development Research, 33(2), 146-156. https://doi.org/10.1002/ddr.430330211