Application of magnetic and luminescent metal oxide particles to biosensors

M. Nichkova, D. Dosev, Z. Ma, S. Gee, B. Hammock, I. Kennedy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanotechnology-based platforms for high-throughput, multiplexed detection of proteins and DNA promise to bring substantial advances in molecular medicine, environmental monitoring and security against terrorist attack. It is possible to replace current chip-based microarray technologies with nanoparticle-based technologies by shifting the immobilizing probe DNA or antibody from the surface of a chip to the surface of a nanoparticle. By incorporating magnetic properties and luminescent properties into the same particle, it is possible to manipulate these materials within tailored magnetic fields, and to achieve sensitive read-out by making use of the non-photobleaching properties of the base lanthanide particle. It is possible to synthesize a large range of uniquely encoded particles using a spray pyrolysis technique that has been perfected in our laboratory, with much greater ease than is offered by embedding quantum dots in polymer beads. In particular, we make use of the unique properties of lanthanide phosphors doped into suitable crystal hosts to synthesize particles with a wide range of ratios of different phosphor signals that encode for unique probe oligonucleotides or antibody probes.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages93-98
Number of pages6
Volume898
DOIs
StatePublished - 2007
Event4th International Workshop on Water Dynamics - Sendai, Japan
Duration: Nov 7 2006Nov 8 2006

Other

Other4th International Workshop on Water Dynamics
CountryJapan
CitySendai
Period11/7/0611/8/06

Fingerprint

magnetic metals
bioinstrumentation
metal oxides
antibodies
phosphors
probes
deoxyribonucleic acid
chips
nanoparticles
environmental monitoring
oligonucleotides
nanotechnology
medicine
beads
embedding
attack
pyrolysis
sprayers
platforms
quantum dots

Keywords

  • Immunoassays
  • Magnetic
  • Nanoparticles

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Nichkova, M., Dosev, D., Ma, Z., Gee, S., Hammock, B., & Kennedy, I. (2007). Application of magnetic and luminescent metal oxide particles to biosensors. In AIP Conference Proceedings (Vol. 898, pp. 93-98) https://doi.org/10.1063/1.2721256

Application of magnetic and luminescent metal oxide particles to biosensors. / Nichkova, M.; Dosev, D.; Ma, Z.; Gee, S.; Hammock, B.; Kennedy, I.

AIP Conference Proceedings. Vol. 898 2007. p. 93-98.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nichkova, M, Dosev, D, Ma, Z, Gee, S, Hammock, B & Kennedy, I 2007, Application of magnetic and luminescent metal oxide particles to biosensors. in AIP Conference Proceedings. vol. 898, pp. 93-98, 4th International Workshop on Water Dynamics, Sendai, Japan, 11/7/06. https://doi.org/10.1063/1.2721256
Nichkova M, Dosev D, Ma Z, Gee S, Hammock B, Kennedy I. Application of magnetic and luminescent metal oxide particles to biosensors. In AIP Conference Proceedings. Vol. 898. 2007. p. 93-98 https://doi.org/10.1063/1.2721256
Nichkova, M. ; Dosev, D. ; Ma, Z. ; Gee, S. ; Hammock, B. ; Kennedy, I. / Application of magnetic and luminescent metal oxide particles to biosensors. AIP Conference Proceedings. Vol. 898 2007. pp. 93-98
@inproceedings{322aa31cc906446ea886495b82a2ca7e,
title = "Application of magnetic and luminescent metal oxide particles to biosensors",
abstract = "Nanotechnology-based platforms for high-throughput, multiplexed detection of proteins and DNA promise to bring substantial advances in molecular medicine, environmental monitoring and security against terrorist attack. It is possible to replace current chip-based microarray technologies with nanoparticle-based technologies by shifting the immobilizing probe DNA or antibody from the surface of a chip to the surface of a nanoparticle. By incorporating magnetic properties and luminescent properties into the same particle, it is possible to manipulate these materials within tailored magnetic fields, and to achieve sensitive read-out by making use of the non-photobleaching properties of the base lanthanide particle. It is possible to synthesize a large range of uniquely encoded particles using a spray pyrolysis technique that has been perfected in our laboratory, with much greater ease than is offered by embedding quantum dots in polymer beads. In particular, we make use of the unique properties of lanthanide phosphors doped into suitable crystal hosts to synthesize particles with a wide range of ratios of different phosphor signals that encode for unique probe oligonucleotides or antibody probes.",
keywords = "Immunoassays, Magnetic, Nanoparticles",
author = "M. Nichkova and D. Dosev and Z. Ma and S. Gee and B. Hammock and I. Kennedy",
year = "2007",
doi = "10.1063/1.2721256",
language = "English (US)",
isbn = "0735404038",
volume = "898",
pages = "93--98",
booktitle = "AIP Conference Proceedings",

}

TY - GEN

T1 - Application of magnetic and luminescent metal oxide particles to biosensors

AU - Nichkova, M.

AU - Dosev, D.

AU - Ma, Z.

AU - Gee, S.

AU - Hammock, B.

AU - Kennedy, I.

PY - 2007

Y1 - 2007

N2 - Nanotechnology-based platforms for high-throughput, multiplexed detection of proteins and DNA promise to bring substantial advances in molecular medicine, environmental monitoring and security against terrorist attack. It is possible to replace current chip-based microarray technologies with nanoparticle-based technologies by shifting the immobilizing probe DNA or antibody from the surface of a chip to the surface of a nanoparticle. By incorporating magnetic properties and luminescent properties into the same particle, it is possible to manipulate these materials within tailored magnetic fields, and to achieve sensitive read-out by making use of the non-photobleaching properties of the base lanthanide particle. It is possible to synthesize a large range of uniquely encoded particles using a spray pyrolysis technique that has been perfected in our laboratory, with much greater ease than is offered by embedding quantum dots in polymer beads. In particular, we make use of the unique properties of lanthanide phosphors doped into suitable crystal hosts to synthesize particles with a wide range of ratios of different phosphor signals that encode for unique probe oligonucleotides or antibody probes.

AB - Nanotechnology-based platforms for high-throughput, multiplexed detection of proteins and DNA promise to bring substantial advances in molecular medicine, environmental monitoring and security against terrorist attack. It is possible to replace current chip-based microarray technologies with nanoparticle-based technologies by shifting the immobilizing probe DNA or antibody from the surface of a chip to the surface of a nanoparticle. By incorporating magnetic properties and luminescent properties into the same particle, it is possible to manipulate these materials within tailored magnetic fields, and to achieve sensitive read-out by making use of the non-photobleaching properties of the base lanthanide particle. It is possible to synthesize a large range of uniquely encoded particles using a spray pyrolysis technique that has been perfected in our laboratory, with much greater ease than is offered by embedding quantum dots in polymer beads. In particular, we make use of the unique properties of lanthanide phosphors doped into suitable crystal hosts to synthesize particles with a wide range of ratios of different phosphor signals that encode for unique probe oligonucleotides or antibody probes.

KW - Immunoassays

KW - Magnetic

KW - Nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=34248168780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248168780&partnerID=8YFLogxK

U2 - 10.1063/1.2721256

DO - 10.1063/1.2721256

M3 - Conference contribution

AN - SCOPUS:34248168780

SN - 0735404038

SN - 9780735404038

VL - 898

SP - 93

EP - 98

BT - AIP Conference Proceedings

ER -